Phenotypes associated with this allele

• Allele Symbol: Gnb1l^{Gt(OST35527)Lex}
• Allele Name: gene trap OST35527, Lexicon Genetics
• Allele ID: MGI:3530640
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnb1l^Gt(OST35527)Lex/Gnb1l^Gt(OST35527)Lex	B6;129S5-Gnb1l^Gt(OST35527)Lex/Orl	MGI:5428437
ht2	Gnb1l^Gt(OST35527)Lex/Gnb1l^+	B6;129S5-Gnb1l^Gt(OST35527)Lex/Orl	MGI:5428438
ht3	Gnb1l^Gt(OST35527)Lex/Gnb1l^+	B6.Cg-Tyr^c-Brd Gnb1l^Gt(OST35527)Lex	MGI:3640307

Genotype
MGI:5428437

hm1

• Allelic Composition: Gnb1l^{Gt(OST35527)Lex}/Gnb1l^{Gt(OST35527)Lex}
• Genetic Background: B6;129S5-Gnb1l^{Gt(OST35527)Lex}/Orl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:82809 )

• lethality of homozygous mutant mice during early gestation

Genotype
MGI:5428438

ht2

• Allelic Composition: Gnb1l^{Gt(OST35527)Lex}/Gnb1l⁺
• Genetic Background: B6;129S5-Gnb1l^{Gt(OST35527)Lex}/Orl

hematopoietic system

abnormal spleen B cell follicle morphology ( J:82809 )

• lymphoid depletion of splenic lymphoid follicles

homeostasis/metabolism

increased circulating bilirubin level ( J:82809 )

• total bilirubin levels were elevated in half of the heterozygous mice and were in the high range for the majority of the remaining heterozygous animals

immune system

abnormal spleen B cell follicle morphology ( J:82809 )

• lymphoid depletion of splenic lymphoid follicles

glomerulonephritis ( J:82809 )

• microscopic analysis revealed membranous glomerulonephritis

renal/urinary system

glomerulonephritis ( J:82809 )

• microscopic analysis revealed membranous glomerulonephritis

Genotype
MGI:3640307

ht3

• Allelic Composition: Gnb1l^{Gt(OST35527)Lex}/Gnb1l⁺
• Genetic Background: B6.Cg-Tyr^c-Brd Gnb1l^{Gt(OST35527)Lex}

nervous system

decreased prepulse inhibition ( J:110101 )

• PPI is significantly impaired; mice have reduced PPI