mortality/aging
• lethality of homozygous mutant mice during early gestation
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Allele Symbol Allele Name Allele ID |
Gnb1lGt(OST35527)Lex gene trap OST35527, Lexicon Genetics MGI:3530640 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lethality of homozygous mutant mice during early gestation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lymphoid depletion of splenic lymphoid follicles
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• total bilirubin levels were elevated in half of the heterozygous mice and were in the high range for the majority of the remaining heterozygous animals
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• lymphoid depletion of splenic lymphoid follicles
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• microscopic analysis revealed membranous glomerulonephritis
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• microscopic analysis revealed membranous glomerulonephritis
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• PPI is significantly impaired; mice have reduced PPI
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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