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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Suz12Gt(Betageo)1Khe
gene trap 1, Kristian Helin
MGI:3530650
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Suz12Gt(Betageo)1Khe/Suz12Gt(Betageo)1Khe involves: 129P2/OlaHsd * C57BL/6 MGI:3531205
ht2
Suz12Gt(Betageo)1Khe/Suz12+ involves: 129P2/OlaHsd MGI:5699869
ht3
Suz12Gt(Betageo)1Khe/Suz12Plt8 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3796625
cx4
Mpltm1Wsa/Mpltm1Wsa
Suz12Gt(Betageo)1Khe/Suz12+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3796626
cx5
Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
Trp53tm1Tyj/Trp53+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5699874
cx6
Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5699877


Genotype
MGI:3531205
hm1
Allelic
Composition
Suz12Gt(Betageo)1Khe/Suz12Gt(Betageo)1Khe
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die during early postimplantation stages, with nearly complete reabsorption of embryos at E10.5 and much smaller embryos at E8.5

cellular
• large number of cells in E7.5 embryos underwent cell death
• E7.5 and E8.5 embryonic cells fail to proliferate

embryo
• large number of cells in E7.5 embryos underwent cell death
• difficult to determine the distinction between the three embryonic sheets
• developmental block at around E7.5
• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos
• the neural ectoderm does not develop, resulting in the complete absence of organogenesis
• amnion was indistinguishable at E7.5
• the amniotic cavity does not form correctly
• the amniotic cavity did not fold around the E8.5 embryo
• chorion was indistinguishable at E7.5 and did not extend around the embryo at E8.5
• the ectoplacental cavity does not form correctly and vacuolated cells were found in the region of the ectoplacental cavity
• the exocoelomic cavity does not form correctly

growth/size/body
• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos

nervous system
• the neural ectoderm does not develop, resulting in the complete absence of organogenesis




Genotype
MGI:5699869
ht2
Allelic
Composition
Suz12Gt(Betageo)1Khe/Suz12+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 20% of mice develop histiocytic sarcoma




Genotype
MGI:3796625
ht3
Allelic
Composition
Suz12Gt(Betageo)1Khe/Suz12Plt8
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
Suz12Plt8 mutation (0 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no compound heterozygous animals were identified at weaning, indicating prenatal lethality




Genotype
MGI:3796626
cx4
Allelic
Composition
Mpltm1Wsa/Mpltm1Wsa
Suz12Gt(Betageo)1Khe/Suz12+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• amelioration of thrombocytopenia compared to Mpltm1Wsa , increased platelet cell number was significant but not to the wild-type level
• thrombocytopenia of Mpltm1Wsa ameliorated, however platelet count is significantly lower than normal wild-type level

immune system
• amelioration of thrombocytopenia compared to Mpltm1Wsa , increased platelet cell number was significant but not to the wild-type level




Genotype
MGI:5699874
cx5
Allelic
Composition
Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (161 available)
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by 150 days

neoplasm
• 12% of mice develop lymphomas
• 62% of mice develop histiocytic sarcomas
• 38% of mice develop malignant peripheral nerve sheath tumors
• tumors develop on average at 2.3 months of age
• 4% of develop angiosarcomas
• 54% of mice develop high-grade gliomas
• gliomas develop on average at 3 months of age

nervous system
• 38% of mice develop malignant peripheral nerve sheath tumors
• tumors develop on average at 2.3 months of age
• 54% of mice develop high-grade gliomas
• gliomas develop on average at 3 months of age




Genotype
MGI:5699877
cx6
Allelic
Composition
Nf1tm1Tyj/Nf1+
Suz12Gt(Betageo)1Khe/Suz12+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (161 available)
Suz12Gt(Betageo)1Khe mutation (1 available); any Suz12 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• 9% of mice develop melanocytic nevi

mortality/aging
• 80% of mice die by 400 days

neoplasm
• 9% of mice develop melanocytic nevi
• 10% of mice develop intestinal adenomas
• 3% of mice develop hepatocellular carcinoma
• 3% of mice develop neurofibromas
• 23% of mice develop lymphoma
• 32% of mice develop histiocytic sarcoma
• 3% of mice develop schwannomas

nervous system
• 3% of mice develop neurofibromas
• 3% of mice develop schwannomas

digestive/alimentary system
• 10% of mice develop intestinal adenomas

liver/biliary system
• 3% of mice develop hepatocellular carcinoma





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory