mortality/aging
• die during early postimplantation stages, with nearly complete reabsorption of embryos at E10.5 and much smaller embryos at E8.5
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cellular
• large number of cells in E7.5 embryos underwent cell death
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• E7.5 and E8.5 embryonic cells fail to proliferate
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embryo
• large number of cells in E7.5 embryos underwent cell death
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• difficult to determine the distinction between the three embryonic sheets
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• developmental block at around E7.5
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• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos
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• the neural ectoderm does not develop, resulting in the complete absence of organogenesis
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• amnion was indistinguishable at E7.5
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• the amniotic cavity does not form correctly
• the amniotic cavity did not fold around the E8.5 embryo
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• chorion was indistinguishable at E7.5 and did not extend around the embryo at E8.5
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• the ectoplacental cavity does not form correctly and vacuolated cells were found in the region of the ectoplacental cavity
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• the exocoelomic cavity does not form correctly
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growth/size/body
• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos
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nervous system
• the neural ectoderm does not develop, resulting in the complete absence of organogenesis
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