About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7bhd
helper deficient
MGI:3530739
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb7bhd/Zbtb7bhd involves: 129/Sv * BALB/c * C3H * C57BL/6 MGI:3573950
cx2
 		Cd8atm1Mak/Cd8atm1Mak
Zbtb7bhd/Zbtb7bhd 		involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd MGI:3573951


Genotype
MGI:3573950
hm1
Allelic
Composition		 Zbtb7bhd/Zbtb7bhd
Genetic
Background		 involves: 129/Sv * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7bhd mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive T cell differentiation ( J:48734 )
• thymic development of CD4 cells is abrogated, with the majority of single positive CD4+ thymocytes being immature CD4+8low rather than CD4+8- cells and the absence of CD69- single-positive CD4+ thymocytes
absent CD4-positive, alpha-beta T cells ( J:48734 )
• lack peripheral single positive CD4+ T cells, however the total numbers of peripheral alpha-beta-TCR+ cells is the same as for wild-type
increased CD8-positive, alpha-beta T cell number ( J:48734 )
• elevated numbers of CD8+ alpha-beta-TCR+ T cells

immune system
abnormal CD4-positive T cell differentiation ( J:48734 )
• thymic development of CD4 cells is abrogated, with the majority of single positive CD4+ thymocytes being immature CD4+8low rather than CD4+8- cells and the absence of CD69- single-positive CD4+ thymocytes
absent CD4-positive, alpha-beta T cells ( J:48734 )
• lack peripheral single positive CD4+ T cells, however the total numbers of peripheral alpha-beta-TCR+ cells is the same as for wild-type
increased CD8-positive, alpha-beta T cell number ( J:48734 )
• elevated numbers of CD8+ alpha-beta-TCR+ T cells

reproductive system
reduced female fertility ( J:48734 )
• female infertility is impaired as intercrosses consistently produce small litters of 2-4 pups




Genotype
MGI:3573951
cx2
Allelic
Composition		 Cd8atm1Mak/Cd8atm1Mak
Zbtb7bhd/Zbtb7bhd
Genetic
Background		 involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (39 available)
Zbtb7bhd mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent CD4-positive, alpha-beta T cells ( J:95867 )
• lack mature, single-positive CD4+ thymocytes or peripheral CD4+ T cells

immune system
absent CD4-positive, alpha-beta T cells ( J:95867 )
• lack mature, single-positive CD4+ thymocytes or peripheral CD4+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory