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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7bhd
helper deficient
MGI:3530739
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb7bhd/Zbtb7bhd involves: 129/Sv * BALB/c * C3H * C57BL/6 MGI:3573950
cx2
 		Cd8atm1Mak/Cd8atm1Mak
Zbtb7bhd/Zbtb7bhd 		involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd MGI:3573951


Genotype
MGI:3573950
hm1
Allelic
Composition		 Zbtb7bhd/Zbtb7bhd
Genetic
Background		 involves: 129/Sv * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7bhd mutation (0 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive T cell differentiation ( J:48734 )
• thymic development of CD4 cells is abrogated, with the majority of single positive CD4+ thymocytes being immature CD4+8low rather than CD4+8- cells and the absence of CD69- single-positive CD4+ thymocytes
absent CD4-positive, alpha-beta T cells ( J:48734 )
• lack peripheral single positive CD4+ T cells, however the total numbers of peripheral alpha-beta-TCR+ cells is the same as for wild-type
increased CD8-positive, alpha-beta T cell number ( J:48734 )
• elevated numbers of CD8+ alpha-beta-TCR+ T cells

immune system
abnormal CD4-positive T cell differentiation ( J:48734 )
• thymic development of CD4 cells is abrogated, with the majority of single positive CD4+ thymocytes being immature CD4+8low rather than CD4+8- cells and the absence of CD69- single-positive CD4+ thymocytes
absent CD4-positive, alpha-beta T cells ( J:48734 )
• lack peripheral single positive CD4+ T cells, however the total numbers of peripheral alpha-beta-TCR+ cells is the same as for wild-type
increased CD8-positive, alpha-beta T cell number ( J:48734 )
• elevated numbers of CD8+ alpha-beta-TCR+ T cells

reproductive system
reduced female fertility ( J:48734 )
• female infertility is impaired as intercrosses consistently produce small litters of 2-4 pups




Genotype
MGI:3573951
cx2
Allelic
Composition		 Cd8atm1Mak/Cd8atm1Mak
Zbtb7bhd/Zbtb7bhd
Genetic
Background		 involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (36 available)
Zbtb7bhd mutation (0 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent CD4-positive, alpha-beta T cells ( J:95867 )
• lack mature, single-positive CD4+ thymocytes or peripheral CD4+ T cells

immune system
absent CD4-positive, alpha-beta T cells ( J:95867 )
• lack mature, single-positive CD4+ thymocytes or peripheral CD4+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory