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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-Nrg1*I)1Kan
transgene insertion 1, Klaus-Armin Nave
MGI:3530750
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Bace1tm1Psa/Bace1tm1Psa
Tg(Thy1-Nrg1*I)1Kan/0 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5524261
tg2
 		Tg(Thy1-Nrg1*I)1Kan/0 involves: 129P2/OlaHsd * C57BL/6 MGI:5524260
tg3
 		Tg(Thy1-Nrg1*I)1Kan/0 Not Specified MGI:3530784


Genotype
MGI:5524261
cx1
Allelic
Composition		 Bace1tm1Psa/Bace1tm1Psa
Tg(Thy1-Nrg1*I)1Kan/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation (0 available); any Bace1 mutation (30 available)
Tg(Thy1-Nrg1*I)1Kan mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
decreased muscle spindle number ( J:199150 )
• as in Bace1tm1Psa homozygotes

nervous system
nervous system phenotype ( J:199150 )
N
• unlike Tg(Thy1-Nrg1*I)1Kan mice, there is no increase in the survival of proprioceptive neurons during the selection phase
decreased muscle spindle number ( J:199150 )
• as in Bace1tm1Psa homozygotes




Genotype
MGI:5524260
tg2
Allelic
Composition		 Tg(Thy1-Nrg1*I)1Kan/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
increased muscle spindle number ( J:199150 )
• in newborn mice persisting through adulthood

nervous system
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
increased muscle spindle number ( J:199150 )
• in newborn mice persisting through adulthood
abnormal proprioceptive neuron morphology ( J:199150 )
• mice exhibit increased survival of proprioceptive neurons during the selection phase compared with wild-type mice




Genotype
MGI:3530784
tg3
Allelic
Composition		 Tg(Thy1-Nrg1*I)1Kan/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
hypermyelination ( J:90038 , J:145464 )
• hypermyelination; thickened myelin sheath observed on the sciatic nerve (J:90038)
• more pronounced for smaller caliber axons than large caliber axons (J:90038)
• many moderately hypermyelinated axons in the white matter due to additional spiral wraps (J:145464)
• extent of remyelination after lysolecthin injection is no greater than for controls (J:145464)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory