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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		RrasGt(OST24882)Lex
gene trap OST24882, Lexicon Genetics
MGI:3530792
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		RrasGt(OST24882)Lex/RrasGt(OST24882)Lex B6;129S5-RrasGt(OST24882)Lex/Ieg MGI:5428696
hm2
 		RrasGt(OST24882)Lex/RrasGt(OST24882)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3616168


Genotype
MGI:5428696
hm1
Allelic
Composition		 RrasGt(OST24882)Lex/RrasGt(OST24882)Lex
Genetic
Background		 B6;129S5-RrasGt(OST24882)Lex/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RrasGt(OST24882)Lex mutation (2 available); any Rras mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:82809 )
• homozygous mutant mice exhibited a decreased mean percentage of B cells
increased CD4-positive, alpha-beta T cell number ( J:82809 )
• homozygous mutant mice exhibited increased mean percentages of both CD4 and CD8 cells
increased CD8-positive, alpha-beta T cell number ( J:82809 )
• homozygous mutant mice exhibited increased mean percentages of both CD4 and CD8 cells

immune system
decreased B cell number ( J:82809 )
• homozygous mutant mice exhibited a decreased mean percentage of B cells
increased CD4-positive, alpha-beta T cell number ( J:82809 )
• homozygous mutant mice exhibited increased mean percentages of both CD4 and CD8 cells
increased CD8-positive, alpha-beta T cell number ( J:82809 )
• homozygous mutant mice exhibited increased mean percentages of both CD4 and CD8 cells




Genotype
MGI:3616168
hm2
Allelic
Composition		 RrasGt(OST24882)Lex/RrasGt(OST24882)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RrasGt(OST24882)Lex mutation (2 available); any Rras mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
artery stenosis ( J:104130 )
• a greater than 3-fold and 10-fold increase in neointimal thickening and Brd-U incorporation, respectively, are seen after injury of the femoral artery designed to mimic restenotic lesions; however no abnormalities are seen in the absence of injury
abnormal physiological neovascularization ( J:104130 )
• increased angiogenesis is seen in matrigel plugs and aortic ring cultures; however no obvious abnormalities are seen in unstressed mice
abnormal tumor vascularization ( J:104130 )
• neovascularization of tumor implants is increased compared to littermate controls
abnormal vascular wound healing ( J:104130 )
• a greater than 3-fold and 10-fold increase in neointimal thickening and Brd-U incorporation, respectively, are seen after injury of the femoral artery

homeostasis/metabolism
abnormal vascular wound healing ( J:104130 )
• a greater than 3-fold and 10-fold increase in neointimal thickening and Brd-U incorporation, respectively, are seen after injury of the femoral artery

neoplasm
abnormal tumor vascularization ( J:104130 )
• neovascularization of tumor implants is increased compared to littermate controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory