Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hmgb1tm1Meb targeted mutation 1, Marco E Bianchi MGI:3530901 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• cultured embryonic fibroblast cells from homozygous mice grow normally, however they show high levels of aneuploidy and spontaneous chromosome aberrations, and display higher rates of damage after UV irradiation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygous mice die within 24 hours after birth
• homozygous mice can survive additional 5-25 days if given glucose intraperitoneally
|
|
• blood glucose levels are normal at birth; however, hypoglycemia develops shortly after birth
|
|
• homozygous mice do not mobilize glycogen stored in liver and develop neonatal hypoglycemia (expression of key enzymes involved in glucose metabolism was not abolished)
|
|
• seen at birth in 8 out 10
|
|
• seen in 6 out 10
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 5 out of 29 homozygotes survived more than 24 hours after birth without glucose treatment; however all were dead by 4 weeks of age
|
|
• most homozygous mice die within 24 hours after birth
|
|
• surviving homozygotes stop growing around 2 weeks of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
