Phenotypes associated with this allele

• Allele Symbol: Mgll^{Gt(OST113734)Lex}
• Allele Name: gene trap OST113734, Lexicon Genetics
• Allele ID: MGI:3530905
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgll^Gt(OST113734)Lex/Mgll^Gt(OST113734)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:4837183

Genotype
MGI:4837183

hm1

• Allelic Composition: Mgll^{Gt(OST113734)Lex}/Mgll^{Gt(OST113734)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:165274 )

• JZL184-treated mice exhibit reduced responses to the antinociceptive and hypothermic effects of delta9-tetrahydrocannabinol (THC) and WIN55,22-2 (a full cannabinoid receptor agonist) compared with similarly treated wild-type mice

• however, mice exhibit normal CB1 agonist-induced catalepsy

decreased chemically-elicited antinociception ( J:165274 )

• JZL184-treated mice exhibit reduced responses to the antinociceptive effects of delta9-tetrahydrocannabinol (THC) and WIN55,22-2 (a full cannabinoid receptor agonist) compared with similarly treated wild-type mice

hypoalgesia ( J:165274 )

• mice exhibit antinociception in an acute thermal tail-withdrawal test and reduced mechanical and cold allodynia in the chronic constrictive injury of the sciatic nerve (CCI) model compared with wild-type mice

• however, treatment with JZL184 restores normal tail-withdrawal latencies in a tail-immersion test for thermal nociception

hyporesponsive to tactile stimuli ( J:165274 )

increased thermal nociceptive threshold ( J:165274 )

• hot and cold

homeostasis/metabolism

increased body temperature ( J:165274 )

• JZL184-treated mice exhibit reduced responses to the hypothermic effects of delta9-tetrahydrocannabinol (THC) and WIN55,22-2 (a full cannabinoid receptor agonist) compared with similarly treated wild-type mice

decreased fatty acids level ( J:165274 )

• mice exhibit a decrease in C20:4 arachidonic acid free fatty acids in the brain compared with wild-type mice

decreased physiological sensitivity to xenobiotic ( J:165274 )

• JZL184-treated mice exhibit reduced responses to the antinociceptive and hypothermic effects of delta9-tetrahydrocannabinol (THC) and WIN55,22-2 (a full cannabinoid receptor agonist) compared with similarly treated wild-type mice