Phenotypes associated with this allele

• Allele Symbol: Gipc1^{Gt(OST93079)Lex}
• Allele Name: gene trap OST93079, Lexicon Genetics
• Allele ID: MGI:3531081
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gipc1^Gt(OST93079)Lex/Gipc1^Gt(OST93079)Lex	B6.129S-Gipc1^Gt(OST93079)Lex	MGI:3715732

Genotype
MGI:3715732

hm1

• Allelic Composition: Gipc1^{Gt(OST93079)Lex}/Gipc1^{Gt(OST93079)Lex}
• Genetic Background: B6.129S-Gipc1^{Gt(OST93079)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:122652 )

• hindlimb vasculature density and fractal dimension are decreased

abnormal vascular branching morphogenesis ( J:122652 )

• endothelial cells have decreased branching formation in vitro

decreased heart weight ( J:122652 )

• mice have decreased heart weight (0.07+/-0.001g) compared to wild-type (0.11+/-0.001g)

abnormal cardiovascular system physiology ( J:122652 )

• mice have decreased ejection fraction, left ventricle fractional shortening, preload-adjusted maximal power, left ventricle stiffness, cardiac arterial volume density, cardiac arterial surface density, and cardiac fractal dimension

increased cardiac output ( J:122652 )

• cardiac output is increased (6397+/-182ul/min) compared to wild-type (9143+/-309ul/min)

decreased cardiac stroke volume ( J:122652 )

• stroke volume in mice is reduced (16.40+/-0.29ul) compared to wild-type (23+/-1.46ul)

decreased heart ventricle muscle contractility ( J:122652 )

• mice have decreased ejection fraction and left ventricle fractional shortening

cellular

decreased cell proliferation ( J:122652 )

• arterial, but not venous cells, have reduced proliferation rates in vitro in response to FGF2, PDGF-BB and VEGF-A₁₆₅

increased cell proliferation ( J:122652 )

• arterial, but not venous cells, have increased proliferation rates in vitro in response to EGF

growth/size/body

decreased body weight ( J:122652 )

• mice weight less (16.7+/-1.3g) compared to wild-type mice (19.9+/-0.5g)

homeostasis/metabolism

impaired wound healing ( J:122652 )

• in a wounding migration assay, arterial, but not venous cells, have reduced velocities in response to 20% serum, FGF2 and VEGF

muscle

decreased heart ventricle muscle contractility ( J:122652 )

• mice have decreased ejection fraction and left ventricle fractional shortening