Analysis Tools
mortality/aging
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• die immediately after birth
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craniofacial
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• defects in the nasal cavity, facial bones and craniofacial cartilage
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• at E14.5, elongates dorsoventrally and expands the dorsal end along the median-lateral axis
• at E16.0 the anterior cartilage is malformed with an ascending branch and reduced ossification around the cartilage
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• increased proliferation of cells at E14.5
• hyperplastic and malformed at E18.5
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• at E18.5
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• fail to form incisor tooth buds
• upper and lower incisor initiation does not occur
• however, molar buds do form
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• at E14.5 the mandible is thickened in the dorsal-ventral axis and shortened in the anterior-posterior axis
• at E18.5, the tongue muscles appear to be fused with the mandible and there is an abnormal ventral bulge in the mandible
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• at E18.5
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• at E18.5
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• abnormal growth of palate tissue at E14.5
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• at E18.5
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• descending palate shelves at E16.5 suggesting a delay in elevation
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• at E14.5 the tongue has a rudimentary root structure but fails to elongate in the anterior-posterior axis
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• at E18.5, the tongue muscles appear to be fused with the mandible
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nervous system
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• many brain structures are undeveloped at E14.5
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• at E12.5
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• the corpus striatum mediale is displaced at E12.5
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• absence of the optic recess at E12.5
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• the trigeminal nerve appears to replace Rathke's pouch
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vision/eye
anophthalmia
(
J:177881
)
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• at E18.5
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hearing/vestibular/ear
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• displaced at E12.5
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endocrine/exocrine glands
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• the trigeminal nerve appears to replace Rathke's pouch
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digestive/alimentary system
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• abnormal growth of palate tissue at E14.5
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• at E18.5
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• descending palate shelves at E16.5 suggesting a delay in elevation
|
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• at E14.5 the tongue has a rudimentary root structure but fails to elongate in the anterior-posterior axis
|
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• at E18.5, the tongue muscles appear to be fused with the mandible
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skeleton
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• at E14.5, elongates dorsoventrally and expands the dorsal end along the median-lateral axis
• at E16.0 the anterior cartilage is malformed with an ascending branch and reduced ossification around the cartilage
|
|
• increased proliferation of cells at E14.5
• hyperplastic and malformed at E18.5
|
|
• at E18.5
|
|
• fail to form incisor tooth buds
• upper and lower incisor initiation does not occur
• however, molar buds do form
|
|
• at E14.5 the mandible is thickened in the dorsal-ventral axis and shortened in the anterior-posterior axis
• at E18.5, the tongue muscles appear to be fused with the mandible and there is an abnormal ventral bulge in the mandible
|
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• at E18.5
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• at E18.5
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• delay in ossification of the sphenoid and basioccipital bones at E16.0
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• membranous ossification of the premaxilla, maxilla, mandible, frontal and parietal bones is missing at E16.0
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embryo
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• at E14.5 the amount of primary cilium is significantly decreased in the mandibular mesenchyme
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growth/size/body
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• at E18.5
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• fail to form incisor tooth buds
• upper and lower incisor initiation does not occur
• however, molar buds do form
|
|
• abnormal growth of palate tissue at E14.5
|
|
• at E18.5
|
|
• descending palate shelves at E16.5 suggesting a delay in elevation
|
|
• at E14.5 the tongue has a rudimentary root structure but fails to elongate in the anterior-posterior axis
|
|
• at E18.5, the tongue muscles appear to be fused with the mandible
|
|
• at E14.5 the amount of primary cilium is significantly decreased in the mandibular mesenchyme
|
