Phenotypes associated with this allele

• Allele Symbol: Cr2^tm1Tft
• Allele Name: targeted mutation 1, Thomas F Tedder
• Allele ID: MGI:3531094
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cr2^tm1Tft/Cr2^tm1Tft	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3531296

Genotype
MGI:3531296

hm1

• Allelic Composition: Cr2^tm1Tft/Cr2^tm1Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased spleen germinal center number ( J:95979 )

• reduced frequency of spleen germinal centers

decreased IgG level ( J:95979 )

• IgG1, IgG2b, and IgG3 levels were reduced in 2-month-old homozygous mice; however, IgG2a and IgA levels were normal

decreased IgG1 level ( J:95979 )

decreased IgG2b level ( J:95979 )

decreased IgG3 level ( J:95979 )

decreased IgM level ( J:95979 )

• serum IgM levels were reduced in 2-month-old homozygous mice

immune system

decreased spleen germinal center number ( J:95979 )

• reduced frequency of spleen germinal centers

abnormal adaptive immunity ( J:95979 )

• decreased T cell-independent and ?dependent antibody responses to low-dose antigens (B cell development is normal)

decreased IgG level ( J:95979 )

• IgG1, IgG2b, and IgG3 levels were reduced in 2-month-old homozygous mice; however, IgG2a and IgA levels were normal

decreased IgG1 level ( J:95979 )

decreased IgG2b level ( J:95979 )

decreased IgG3 level ( J:95979 )

decreased IgM level ( J:95979 )

• serum IgM levels were reduced in 2-month-old homozygous mice

increased susceptibility to bacterial infection ( J:95979 )

• homozygous mice were more susceptible to acute lethal Streptococcus pneumoniae infection (early innate responses required to survive S. pneumoniae infection in the absence of previous exposure were normal)