Phenotypes associated with this allele

• Allele Symbol: Mtm1^{Gt(OST290577)Lex}
• Allele Name: gene trap OST290577, Lexicon Genetics
• Allele ID: MGI:3531156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Mtm1^Gt(OST290577)Lex/Y	involves: 129S5/SvEvBrd * C57BL/6	MGI:5469203

Genotype
MGI:5469203

ot1

• Allelic Composition: Mtm1^{Gt(OST290577)Lex}/Y
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired autophagy ( J:192845 )

♂ • impaired in muscle

muscle

abnormal Z line morphology ( J:192845 )

♂ • wavy, misaligned

decreased skeletal muscle fiber size ( J:192845 )

♂ • with reduced cross-sectional area

centrally nucleated skeletal muscle fibers ( J:192845 )

♂ • central or, more often, paracentral nuclei

decreased muscle weight ( J:192845 )

♂

myopathy ( J:192845 )

♂ • progressive

cellular

impaired autophagy ( J:192845 )

♂ • impaired in muscle

abnormal mitochondrial physiology ( J:192845 )

♂ • COX enzyme activity is reduced in muscle mitochondria

oxidative stress ( J:192845 )

♂ • robust induction of oxidative stress response enzyme in muscles

growth/size/body

decreased body weight ( J:192845 )

♂ • progressive, starting at 4 weeks

behavior/neurological

decreased grip strength ( J:192845 )

♂ • progressive in the forelimb