Phenotypes associated with this allele

• Allele Symbol: C1galt1^tm1Rpmc
• Allele Name: targeted mutation 1, Roger P McEver
• Allele ID: MGI:3531503
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C1galt1^tm1Rpmc/C1galt1^tm1Rpmc	involves: 129S1/Sv * C57BL/6J	MGI:3573758

Genotype
MGI:3573758

hm1

• Allelic Composition: C1galt1^tm1Rpmc/C1galt1^tm1Rpmc
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fatal embryonic hemorrhage in C1galt1^tm1Rpmc/C1galt1^tm1Rpmc mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:96775 )

• mutants die between E13 and E14; all dead by E14

cardiovascular system

abnormal vascular endothelial cell morphology ( J:96775 )

• capillary endothelial cells have distorted shapes, focal cytoplasmic thinning and enlarged extracellular spaces around the pericytes and endothelial cells

abnormal capillary morphology ( J:96775 )

• capillaries in the brain have irregular or dilated lumens, have pericytes that lack the normal close apposition to the endothelial cells, and have enlarged extracellular spaces around the pericytes and endothelial cells

• abnormalities precede hemorrhages and tend to be more severe near hemorrhage

dilated capillary ( J:96775 )

abnormal vascular branching morphogenesis ( J:96775 )

• in the brain parenchyma the microvasculature is chaotic with irregular capillary diameters and disordered branching

• in the yolk sac increased capillary branching and irregular vessel diameters are seen

intracranial hemorrhage ( J:96775 )

• hemorrhages in the brain parenchyma with secondary bleeding into the ventricles are seen, however blood clotting is normal

spinal hemorrhage ( J:96775 )

• hemorrhages in the spinal cord with secondary bleeding into the spinal canal are seen

hematopoietic system

anemia ( J:96775 )

• secondary to hemorrhages

nervous system

intracranial hemorrhage ( J:96775 )

• hemorrhages in the brain parenchyma with secondary bleeding into the ventricles are seen, however blood clotting is normal

spinal hemorrhage ( J:96775 )

• hemorrhages in the spinal cord with secondary bleeding into the spinal canal are seen