Phenotypes associated with this allele

• Allele Symbol: Slc19a1^tm1Rsc
• Allele Name: targeted mutation 1, Robert S Chapkin
• Allele ID: MGI:3573752
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc19a1^tm1Rsc/Slc19a1^tm1Rsc	involves: 129P2/OlaHsd * SWV/Fnn	MGI:3575528
ht2	Slc19a1^tm1Rsc/Slc19a1^+	involves: 129P2/OlaHsd * SWV/Fnn	MGI:3575529

Genotype
MGI:3575528

hm1

• Allelic Composition: Slc19a1^tm1Rsc/Slc19a1^tm1Rsc
• Genetic Background: involves: 129P2/OlaHsd * SWV/Fnn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:96380 )

• lethality can not be rescued by supplementation of the dams diet with folate

Genotype
MGI:3575529

ht2

• Allelic Composition: Slc19a1^tm1Rsc/Slc19a1⁺
• Genetic Background: involves: 129P2/OlaHsd * SWV/Fnn

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:96380 )

• the proliferative zone is enlarged

abnormal colon morphology ( J:96380 )

• colonocyte proliferation is significantly increased

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:96380 )

• the proliferative zone is enlarged

homeostasis/metabolism

abnormal homeostasis ( J:96380 )

• the ratio of S-adenosylmethionine to S-adenosylhomocysteine is decreased in the plasma

increased physiological sensitivity to xenobiotic ( J:96380 )

• 8 weeks after treatment with azoxymethane more aberrant crypts per focus are found in heterozygotes compared to wild-type mice

• 38 weeks after treatment with azoxymethane, inflammatory lesion size is increased however the number of lesions is the same as in wild-type mice