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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		KitWads
white anemic deaf sterile
MGI:3573757
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		KitWads/KitWads C57BL/6J-KitWads MGI:3573946
ht2
 		KitWads/Kit+ C57BL/6J-KitWads MGI:3573948
ht3
 		KitWads/Kit+ involves: C57BL/6J MGI:4822203
ht4
 		KitWads/KitWps involves: C57BL/6J * CBA/CaJ MGI:5523969


Genotype
MGI:3573946
hm1
Allelic
Composition		 KitWads/KitWads
Genetic
Background		 C57BL/6J-KitWads
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitWads mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal stria vascularis morphology ( J:96391 )
• expression of connexins 26 and 30 is disorganized suggesting disruption of gap junctions at the base of the stria vascularis
abnormal stria vascularis vasculature morphology ( J:96391 )
• loss of blood capillaries at 1 month of age; more disorganization and depletion of blood vessels observed at 1 year of age
absent strial intermediate cells ( J:96391 )
• loss of strial intermediate cells at 1 month of age
increased or absent threshold for auditory brainstem response ( J:96391 )
• ABR response waves were absent in homozygous mice at 1 month of age

hematopoietic system
decreased mast cell number ( J:96391 )
• no mast cells were observed in homozygous skin tissues

reproductive system
absent ovarian follicles ( J:96391 )
• no primordial or mature ovarian follicles were present in mutant ovaries; only granulose cells were present in adult ovaries
increased Leydig cell number ( J:96391 )
• increase of the number of Leydig cells due to enhanced mitotic activity
small testis ( J:96391 )
• gross size of the testes is smaller than in controls
arrest of spermatogenesis ( J:96391 )
• germ cells did not proliferate and differentiate

endocrine/exocrine glands
absent ovarian follicles ( J:96391 )
• no primordial or mature ovarian follicles were present in mutant ovaries; only granulose cells were present in adult ovaries
increased Leydig cell number ( J:96391 )
• increase of the number of Leydig cells due to enhanced mitotic activity
small testis ( J:96391 )
• gross size of the testes is smaller than in controls

pigmentation
absent strial intermediate cells ( J:96391 )
• loss of strial intermediate cells at 1 month of age
absent coat pigmentation ( J:96391 )
• all white hair
abnormal skin pigmentation ( J:96391 )
• all white skin, but black eyes

immune system
decreased mast cell number ( J:96391 )
• no mast cells were observed in homozygous skin tissues

nervous system

cardiovascular system
abnormal stria vascularis vasculature morphology ( J:96391 )
• loss of blood capillaries at 1 month of age; more disorganization and depletion of blood vessels observed at 1 year of age

integument
absent coat pigmentation ( J:96391 )
• all white hair
abnormal skin pigmentation ( J:96391 )
• all white skin, but black eyes




Genotype
MGI:3573948
ht2
Allelic
Composition		 KitWads/Kit+
Genetic
Background		 C57BL/6J-KitWads
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitWads mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:96391 )
• a symmetrical cluster of white coat on the abdomen was observed
head spot ( J:96391 )
• incomplete penetrance; some animals have a head spot
variable body spotting ( J:96391 )
• small white spots on the back were observed
• most of the tail and the distal part of the legs displayed a white color

hematopoietic system
increased mean platelet volume ( J:96391 )
• slight elevation compared to controls

integument
belly spot ( J:96391 )
• a symmetrical cluster of white coat on the abdomen was observed
head spot ( J:96391 )
• incomplete penetrance; some animals have a head spot
variable body spotting ( J:96391 )
• small white spots on the back were observed
• most of the tail and the distal part of the legs displayed a white color




Genotype
MGI:4822203
ht3
Allelic
Composition		 KitWads/Kit+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitWads mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:163026 )
• mice exhibit contorted seminiferous tubules unlike wild-type mice

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:163026 )
• mice exhibit contorted seminiferous tubules unlike wild-type mice




Genotype
MGI:5523969
ht4
Allelic
Composition		 KitWads/KitWps
Genetic
Background		 involves: C57BL/6J * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitWads mutation (0 available); any Kit mutation (182 available)
KitWps mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
absent coat pigmentation ( J:196572 )
• fully white coat as in KitWads homozygotes

pigmentation
absent coat pigmentation ( J:196572 )
• fully white coat as in KitWads homozygotes




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory