hearing/vestibular/ear
• expression of connexins 26 and 30 is disorganized suggesting disruption of gap junctions at the base of the stria vascularis
|
• loss of blood capillaries at 1 month of age; more disorganization and depletion of blood vessels observed at 1 year of age
|
• loss of strial intermediate cells at 1 month of age
|
• ABR response waves were absent in homozygous mice at 1 month of age
|
hematopoietic system
• no mast cells were observed in homozygous skin tissues
|
reproductive system
|
• no primordial or mature ovarian follicles were present in mutant ovaries; only granulose cells were present in adult ovaries
|
small ovary
(
J:96391
)
|
|
|
• increase of the number of Leydig cells due to enhanced mitotic activity
|
small testis
(
J:96391
)
|
• gross size of the testes is smaller than in controls
|
|
• germ cells did not proliferate and differentiate
|
endocrine/exocrine glands
|
• no primordial or mature ovarian follicles were present in mutant ovaries; only granulose cells were present in adult ovaries
|
small ovary
(
J:96391
)
|
|
|
• increase of the number of Leydig cells due to enhanced mitotic activity
|
small testis
(
J:96391
)
|
• gross size of the testes is smaller than in controls
|
pigmentation
• loss of strial intermediate cells at 1 month of age
|
• all white hair
|
• all white skin, but black eyes
|
immune system
• no mast cells were observed in homozygous skin tissues
|
nervous system
cardiovascular system
• loss of blood capillaries at 1 month of age; more disorganization and depletion of blood vessels observed at 1 year of age
|
integument
• all white hair
|
• all white skin, but black eyes
|