Analysis Tools|
Allele Symbol Allele Name Allele ID |
Trp53tm1Att targeted mutation 1, Laura D Attardi MGI:3573778 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• similar to Trp53 null cells, the percentage of cells in S phase is increased compared to wild-type cells
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• in the absence of cre, MEFs are refractory to stress-induced cell death
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there is only a small reduction in the number of cells in S phase following adenoviral cre infection, and this percentage is still higher than in wild-type MEFs
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• MEFs infected with adenoviral cre and treated with doxorubicin show only a moderate decrease in the percentage of cells in S phase indicating an impaired G1 arrest response
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• cell cycle is not arrested by gamma irradiation after treatment with adenovirus-cre
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• following adenoviral cre infection, MEFs remain refractory to UV-C-induced cell death but not hypoxia-induced cell death
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no apoptosis in mice treated with tamoxifen measured 6 hours after radiation treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit markedly darkened ears relative to control mice
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• mice exhibit markedly darkened hair relative to control mice
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• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
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• mice exhibit markedly darkened tails relative to control mice
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• mice exhibit markedly darkened ears relative to control mice
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• mice exhibit markedly darkened hair relative to control mice
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• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
|
|
• mice exhibit markedly darkened tails relative to control mice
|
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• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
|
|
• mice exhibit markedly darkened tails relative to control mice
|
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• mice exhibit markedly darkened ears relative to control mice
|
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• mice exhibit markedly darkened ears relative to control mice
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• mice exhibit markedly darkened ears relative to control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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