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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm1Att
targeted mutation 1, Laura D Attardi
MGI:3573778
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp53tm1Att/Trp53tm1Att involves: 129S4/SvJae MGI:3717084
cn2
Trp53tm1Att/Trp53tm1Att involves: 129S4/SvJae MGI:3717083
cn3
Trp53tm1Att/Trp53tm1Att
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
involves: 129S4/SvJae MGI:5140097
cn4
Trp53tm1Att/Trp53+
Tg(KRT5-cre)5132Jlj/0
involves: 129S4/SvJae * C57BL/6J * DBA/2J MGI:6260009


Genotype
MGI:3717084
hm1
Allelic
Composition
Trp53tm1Att/Trp53tm1Att
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Att mutation (1 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• similar to Trp53 null cells, the percentage of cells in S phase is increased compared to wild-type cells
• in the absence of cre, MEFs are refractory to stress-induced cell death




Genotype
MGI:3717083
cn2
Allelic
Composition
Trp53tm1Att/Trp53tm1Att
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Att mutation (1 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• there is only a small reduction in the number of cells in S phase following adenoviral cre infection, and this percentage is still higher than in wild-type MEFs
• MEFs infected with adenoviral cre and treated with doxorubicin show only a moderate decrease in the percentage of cells in S phase indicating an impaired G1 arrest response
• cell cycle is not arrested by gamma irradiation after treatment with adenovirus-cre
• following adenoviral cre infection, MEFs remain refractory to UV-C-induced cell death but not hypoxia-induced cell death




Genotype
MGI:5140097
cn3
Allelic
Composition
Trp53tm1Att/Trp53tm1Att
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Trp53tm1Att mutation (1 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• no apoptosis in mice treated with tamoxifen measured 6 hours after radiation treatment




Genotype
MGI:6260009
cn4
Allelic
Composition
Trp53tm1Att/Trp53+
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-cre)5132Jlj mutation (1 available)
Trp53tm1Att mutation (1 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice exhibit markedly darkened ears relative to control mice
• mice exhibit markedly darkened hair relative to control mice
• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
• mice exhibit markedly darkened tails relative to control mice

integument
• mice exhibit markedly darkened ears relative to control mice
• mice exhibit markedly darkened hair relative to control mice
• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
• mice exhibit markedly darkened tails relative to control mice

limbs/digits/tail
• mice exhibit markedly darkened footpads relative to control mice
• Kitl mRNA expression is increased 5.5-fold in the footpad epidermis relative to control mice
• mice exhibit markedly darkened tails relative to control mice

craniofacial
• mice exhibit markedly darkened ears relative to control mice

hearing/vestibular/ear
• mice exhibit markedly darkened ears relative to control mice

growth/size/body
• mice exhibit markedly darkened ears relative to control mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory