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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(Gphb5)Lmac
targeted mutation 1, Lynn E Macdonald
MGI:3573780
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gt(ROSA)26Sortm1(Gphb5)Lmac/Gt(ROSA)26Sor+ Not Specified MGI:3575743


Genotype
MGI:3575743
ht1
Allelic
Composition
Gt(ROSA)26Sortm1(Gphb5)Lmac/Gt(ROSA)26Sor+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gphb5)Lmac mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• heart rate, diastolic and systolic blood pressure, and pulse pressure tend to be slightly elevated but are within normal limits

craniofacial
• the frontal bone is significantly shorter; however the parietal bone is normal
• the nasal bone is significantly shorter

growth/size/body
• the nasal bone is significantly shorter
• first seen at about 1 month of age but transgenics tend to eat slightly more than wild-type mice
• when placed on a high fat diet male and to a lesser extent female transgenic gain less weight and adipose tissue than wild-type mice

homeostasis/metabolism
• when placed on a high fat diet male and to a lesser extent female transgenic gain less weight and adipose tissue than wild-type mice
• increased 1.5- to 2-fold in both males and females; however, TSH levels were not increased
• increased 1.5- to 2-fold in both males and females; however, TSH levels were not increased
• transgenics consume more oxygen per unit body weight compared to wild-type mice on either a normal or high fat diet

skeleton
• the frontal bone is significantly shorter; however the parietal bone is normal
• the nasal bone is significantly shorter

respiratory system
• the nasal bone is significantly shorter





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory