Analysis Tools
reproductive system
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• the number of spermatozoa is reduced to about 7% of that in heterozygous littermates in most but not all homozygous males
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• elongated spermatids are rarely seen
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• apoptotic spermatocytes are seen in 58% of seminiferous tubules
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• most of the remaining sperm had impaired motility
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• Sertoli cells become round, lose contact with the basement membrane, dislocate toward the lumen of the tubule, and are incapable of supporting round spermatid differentiation
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• degeneration varied from mild with intraepithelial vacuoles of varying sizes to severe atrophy of the tubules
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small testis
(
J:96238
)
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• male but not female fertility is reduced
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growth/size/body
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• homozygous males but not females have reduced body weights compared to heterozygous littermates
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• homozygous males but not females have reduced growth compared to heterozygous littermates with the growth curve for homozygous males coinciding with that of females
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endocrine/exocrine glands
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• Sertoli cells become round, lose contact with the basement membrane, dislocate toward the lumen of the tubule, and are incapable of supporting round spermatid differentiation
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• degeneration varied from mild with intraepithelial vacuoles of varying sizes to severe atrophy of the tubules
|
small testis
(
J:96238
)
|
|
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cellular
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• the number of spermatozoa is reduced to about 7% of that in heterozygous littermates in most but not all homozygous males
|
|
|
• elongated spermatids are rarely seen
|
|
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• apoptotic spermatocytes are seen in 58% of seminiferous tubules
|
|
|
• most of the remaining sperm had impaired motility
|
