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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Elf5tm1Mapr
targeted mutation 1, Melanie A Pritchard
MGI:3573855
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Elf5tm1Mapr/Elf5tm1Mapr involves: 129S4/SvJae * C57BL/6J MGI:3573954
ht2
Elf5tm1Mapr/Elf5+ involves: 129S4/SvJae * 129T2/SvEms * C57BL/6J MGI:3573956
ht3
Elf5tm1Mapr/Elf5+ involves: 129S4/SvJae * C57BL/6J MGI:3573955


Genotype
MGI:3573954
hm1
Allelic
Composition
Elf5tm1Mapr/Elf5tm1Mapr
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Mapr mutation (1 available); any Elf5 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos are present at E3.5 but not found at E7.5




Genotype
MGI:3573956
ht2
Allelic
Composition
Elf5tm1Mapr/Elf5+
Genetic
Background
involves: 129S4/SvJae * 129T2/SvEms * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Mapr mutation (1 available); any Elf5 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: all heterozygous females resulting from backcrosses to 129T2/SvEms failed to lactate even after multiple pregnancies

integument
• Background Sensitivity: all heterozygous females resulting from backcrosses to 129T2/SvEms failed to lactate even after multiple pregnancies




Genotype
MGI:3573955
ht3
Allelic
Composition
Elf5tm1Mapr/Elf5+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Mapr mutation (1 available); any Elf5 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• initial development of the mammary gland is normal however development stalls during the proliferation phase resulting in retarded alveolar genesis
• most females are unable to lactate or have impaired lactation
• about 84% of heterozygous females fail to support any pups and about 6% were able to support a reduced number of pups
• Background Sensitivity: this phenotype becomes fully penetrant when backcrossed onto 129T2/SvEms

integument
• initial development of the mammary gland is normal however development stalls during the proliferation phase resulting in retarded alveolar genesis
• most females are unable to lactate or have impaired lactation
• about 84% of heterozygous females fail to support any pups and about 6% were able to support a reduced number of pups
• Background Sensitivity: this phenotype becomes fully penetrant when backcrossed onto 129T2/SvEms





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory