mortality/aging
• homozygous embryos are present at E3.5 but not found at E7.5
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Allele Symbol Allele Name Allele ID |
Elf5tm1Mapr targeted mutation 1, Melanie A Pritchard MGI:3573855 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygous embryos are present at E3.5 but not found at E7.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: all heterozygous females resulting from backcrosses to 129T2/SvEms failed to lactate even after multiple pregnancies
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• Background Sensitivity: all heterozygous females resulting from backcrosses to 129T2/SvEms failed to lactate even after multiple pregnancies
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• initial development of the mammary gland is normal however development stalls during the proliferation phase resulting in retarded alveolar genesis
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• most females are unable to lactate or have impaired lactation
• about 84% of heterozygous females fail to support any pups and about 6% were able to support a reduced number of pups
• Background Sensitivity: this phenotype becomes fully penetrant when backcrossed onto 129T2/SvEms
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• initial development of the mammary gland is normal however development stalls during the proliferation phase resulting in retarded alveolar genesis
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• most females are unable to lactate or have impaired lactation
• about 84% of heterozygous females fail to support any pups and about 6% were able to support a reduced number of pups
• Background Sensitivity: this phenotype becomes fully penetrant when backcrossed onto 129T2/SvEms
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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