About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elf5tm1Mapr
targeted mutation 1, Melanie A Pritchard
MGI:3573855
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Elf5tm1Mapr/Elf5tm1Mapr involves: 129S4/SvJae * C57BL/6J MGI:3573954
ht2
 		Elf5tm1Mapr/Elf5+ involves: 129S4/SvJae * 129T2/SvEms * C57BL/6J MGI:3573956
ht3
 		Elf5tm1Mapr/Elf5+ involves: 129S4/SvJae * C57BL/6J MGI:3573955


Genotype
MGI:3573954
hm1
Allelic
Composition		 Elf5tm1Mapr/Elf5tm1Mapr
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Mapr mutation (1 available); any Elf5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:96237 )
• homozygous embryos are present at E3.5 but not found at E7.5




Genotype
MGI:3573956
ht2
Allelic
Composition		 Elf5tm1Mapr/Elf5+
Genetic
Background		 involves: 129S4/SvJae * 129T2/SvEms * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Mapr mutation (1 available); any Elf5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
lactation failure ( J:96237 )
• Background Sensitivity: all heterozygous females resulting from backcrosses to 129T2/SvEms failed to lactate even after multiple pregnancies

integument
lactation failure ( J:96237 )
• Background Sensitivity: all heterozygous females resulting from backcrosses to 129T2/SvEms failed to lactate even after multiple pregnancies




Genotype
MGI:3573955
ht3
Allelic
Composition		 Elf5tm1Mapr/Elf5+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elf5tm1Mapr mutation (1 available); any Elf5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland development ( J:96237 )
• initial development of the mammary gland is normal however development stalls during the proliferation phase resulting in retarded alveolar genesis
abnormal lactation ( J:96237 )
• most females are unable to lactate or have impaired lactation
• about 84% of heterozygous females fail to support any pups and about 6% were able to support a reduced number of pups
• Background Sensitivity: this phenotype becomes fully penetrant when backcrossed onto 129T2/SvEms

integument
abnormal mammary gland development ( J:96237 )
• initial development of the mammary gland is normal however development stalls during the proliferation phase resulting in retarded alveolar genesis
abnormal lactation ( J:96237 )
• most females are unable to lactate or have impaired lactation
• about 84% of heterozygous females fail to support any pups and about 6% were able to support a reduced number of pups
• Background Sensitivity: this phenotype becomes fully penetrant when backcrossed onto 129T2/SvEms




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory