Phenotypes associated with this allele

• Allele Symbol: Cdh17^tm1Ohn
• Allele Name: targeted mutation 1, Kazuo Ohnishi
• Allele ID: MGI:3573870
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh17^tm1Ohn/Cdh17^tm1Ohn	involves: 129P2/OlaHsd * C57BL/6	MGI:3576469

Genotype
MGI:3576469

hm1

• Allelic Composition: Cdh17^tm1Ohn/Cdh17^tm1Ohn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased pro-B cell number ( J:96738 )

• the B220^loc-Kit⁺ population of proB-cells in the bone marrow was increased to about two-to-threefold

decreased B cell number ( J:96738 )

decreased mature B cell number ( J:96738 )

• the B220^hi population of mostly mature B cells in the bone marrow was reduced to about 60%

decreased germinal center B cell number ( J:96738 )

• in the spleen, B220⁺PNA⁺germinal center B cells are reduced to about 60%

decreased B-1a cell number ( J:96738 )

• IgM⁺Mac-1⁺CD5⁺ B1a cells were reduced on average by 30% in the peritoneal cavity

decreased marginal zone B cell number ( J:96738 )

• in the spleen, CD21^hiCD23^lo marginal zone B cells are reduced to about 60%

increased pre-B cell number ( J:96738 )

• the B220^loc-Kit⁺ population of preBI-cells in the bone marrow was increased to about two-to-threefold

decreased spleen germinal center size ( J:96738 )

• spleen germinal center size was significantly smaller

abnormal spleen marginal zone morphology ( J:96738 )

• shape of areas of marginal zone B cells appeared less condensed compared to wildtype

decreased IgG level ( J:96738 )

• IgG1 and IgG3 responses to the T-independent antigen, NP-Ficoll, were significantly reduced, however responsiveness of IgM, IgG2a and IgG2b were not altered and responses to T-dependent antigen, DNP-KLH were not affected

hematopoietic system

increased pro-B cell number ( J:96738 )

• the B220^loc-Kit⁺ population of proB-cells in the bone marrow was increased to about two-to-threefold

decreased B cell number ( J:96738 )

decreased mature B cell number ( J:96738 )

• the B220^hi population of mostly mature B cells in the bone marrow was reduced to about 60%

decreased germinal center B cell number ( J:96738 )

• in the spleen, B220⁺PNA⁺germinal center B cells are reduced to about 60%

decreased B-1a cell number ( J:96738 )

• IgM⁺Mac-1⁺CD5⁺ B1a cells were reduced on average by 30% in the peritoneal cavity

decreased marginal zone B cell number ( J:96738 )

• in the spleen, CD21^hiCD23^lo marginal zone B cells are reduced to about 60%

increased pre-B cell number ( J:96738 )

• the B220^loc-Kit⁺ population of preBI-cells in the bone marrow was increased to about two-to-threefold

decreased spleen germinal center size ( J:96738 )

• spleen germinal center size was significantly smaller

abnormal spleen marginal zone morphology ( J:96738 )

• shape of areas of marginal zone B cells appeared less condensed compared to wildtype

decreased IgG level ( J:96738 )

• IgG1 and IgG3 responses to the T-independent antigen, NP-Ficoll, were significantly reduced, however responsiveness of IgM, IgG2a and IgG2b were not altered and responses to T-dependent antigen, DNP-KLH were not affected