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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-Obvic1
virus infectivity controller 1
MGI:3573873
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2-Obvic1/H2-Obvic1 B6.I-H2-Obvic1 MGI:6189195
hm2
 		H2-Obvic1/H2-Obvic1 C3N.I-H2-Obvic1 MGI:6189192
hm3
 		H2-Obvic1/H2-Obvic1 C.I-H2-Obvic1 MGI:6189197
hm4
 		H2-Obvic1/H2-Obvic1 I/LnJ MGI:4822379


Genotype
MGI:6189195
hm1
Allelic
Composition		 H2-Obvic1/H2-Obvic1
Genetic
Background		 B6.I-H2-Obvic1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Retroviridae infection ( J:254532 )
• virus-neutralizing immune response is generated in response to infection with retroviruses




Genotype
MGI:6189192
hm2
Allelic
Composition		 H2-Obvic1/H2-Obvic1
Genetic
Background		 C3N.I-H2-Obvic1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Retroviridae infection ( J:254532 )
• virus-neutralizing immune response is generated in response to infection with retroviruses




Genotype
MGI:6189197
hm3
Allelic
Composition		 H2-Obvic1/H2-Obvic1
Genetic
Background		 C.I-H2-Obvic1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Retroviridae infection ( J:254532 )
• virus-neutralizing immune response is generated in response to infection with retroviruses




Genotype
MGI:4822379
hm4
Allelic
Composition		 H2-Obvic1/H2-Obvic1
Genetic
Background		 I/LnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Retroviridae infection ( J:163153 )
• although MMTV and MuLV infection can occur, MMTV transmission and mammary tumor induction are blocked and MuLV transmission and virally induced disease are blocked, and these responses are mediated by anti-virion antibodies, require gamma interferon, cytotoxic immune responses, but not interleukin 12

neoplasm
decreased incidence of induced tumors ( J:60602 , J:81554 )
• mammary glands become infected with MMTV but at 1.5 years zero of 24 infected females develop tumors (J:81554)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory