Analysis Tools
mortality/aging
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• 40% of homozygous embryos begin to die around E13.5
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• about 55% of homozygous embryos die perinatally
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• in heterozygous crosses only 4.4% of pups at weaning are homozygous
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cardiovascular system
hemorrhage
(
J:96758
)
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• 40% of homozygous embryos had abdominal, cranial, and hepatic bleeding
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growth/size/body
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• surviving homozygotes are smaller than their littermates
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hematopoietic system
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• platelet aggregation in response to collagen, convulxin (snake venom), an F2RL3 activating peptide, or a calcium ionophore (A23187) is reduced
• however, similar to wild-type, P2RY1 and P2RY12 antagonists can block aggregation
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reproductive system
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• crosses between surviving homozygotes produce 45% smaller litters at weaning; however more homozygous pups survive compared to heterozygous crosses
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homeostasis/metabolism
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• platelet aggregation in response to collagen, convulxin (snake venom), an F2RL3 activating peptide, or a calcium ionophore (A23187) is reduced
• however, similar to wild-type, P2RY1 and P2RY12 antagonists can block aggregation
|
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• homozygotes begin to form thrombi in a platelet-dependent carotid artery thrombosis model however vessel occlusion is not seen
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