About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp384tm1Tnk
targeted mutation 1, Tetsuya Nakamoto
MGI:3573930
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp384tm1Tnk/Zfp384tm1Tnk involves: C57BL/6 * CBA MGI:3575515
ht2
 		Zfp384tm1Tnk/Zfp384+ involves: C57BL/6 * CBA MGI:3575518


Genotype
MGI:3575515
hm1
Allelic
Composition		 Zfp384tm1Tnk/Zfp384tm1Tnk
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp384tm1Tnk mutation (0 available); any Zfp384 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:96747 )
• variable degree of defects in seminiferous tubules with some lacking all spermatogenic cell types and occupied by Sertoli cells only, however no changes in Leydig cells or Sertoli cells or in the epididymis
seminiferous tubule degeneration ( J:96747 )
• reduction in spermatogenic cell number in the tubules
• increased apoptosis of spermatogenic cells at 4 weeks, 8 weeks and 5 months of age
decreased testis weight ( J:96747 )
• the weight of testes were on average 72% of that of wildtype

growth/size/body
decreased body size ( J:96747 )
• smaller body size that is retained throughout adulthood in both males and females

reproductive system
abnormal seminiferous tubule morphology ( J:96747 )
• variable degree of defects in seminiferous tubules with some lacking all spermatogenic cell types and occupied by Sertoli cells only, however no changes in Leydig cells or Sertoli cells or in the epididymis
seminiferous tubule degeneration ( J:96747 )
• reduction in spermatogenic cell number in the tubules
• increased apoptosis of spermatogenic cells at 4 weeks, 8 weeks and 5 months of age
decreased testis weight ( J:96747 )
• the weight of testes were on average 72% of that of wildtype
male infertility ( J:96747 )
• homozygote males were partially infertile with a large variability in the age onset of sterility

skeleton
skeleton phenotype ( J:96747 )
N
• no abnormalities in bone structure




Genotype
MGI:3575518
ht2
Allelic
Composition		 Zfp384tm1Tnk/Zfp384+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp384tm1Tnk mutation (0 available); any Zfp384 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased testis weight ( J:96747 )
• average testis weight was between that of wildtype and homozygous mutants (smaller than in wildtype but larger than in homozygotes), however no histological defect in the testes nor reduced infertility were observed

reproductive system
decreased testis weight ( J:96747 )
• average testis weight was between that of wildtype and homozygous mutants (smaller than in wildtype but larger than in homozygotes), however no histological defect in the testes nor reduced infertility were observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory