Phenotypes associated with this allele

• Allele Symbol: Stxbp3^tm1Jpes
• Allele Name: targeted mutation 1, Jeffrey Pessin
• Allele ID: MGI:3573931
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stxbp3^tm1Jpes/Stxbp3^tm1Jpes	B6.129-Stxbp3^tm1Jpes	MGI:3575526
ht2	Stxbp3^tm1Jpes/Stxbp3^+	B6.129-Stxbp3^tm1Jpes	MGI:3575527

Genotype
MGI:3575526

hm1

• Allelic Composition: Stxbp3^tm1Jpes/Stxbp3^tm1Jpes
• Genetic Background: B6.129-Stxbp3^tm1Jpes

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:96731 )

• embryos died before E7.5

Genotype
MGI:3575527

ht2

• Allelic Composition: Stxbp3^tm1Jpes/Stxbp3⁺
• Genetic Background: B6.129-Stxbp3^tm1Jpes

endocrine/exocrine glands

decreased insulin secretion ( J:96731 )

• glucose-stimulated insulin secretion was significantly decreased in islets

homeostasis/metabolism

decreased insulin secretion ( J:96731 )

• glucose-stimulated insulin secretion was significantly decreased in islets

hyperglycemia ( J:96731 )

• after 10 weeks on a high-fat diet, had significantly increased fasting blood glucose indicating susceptibility for developing hyperglycemia however serum triglyceride levels were normal

impaired glucose tolerance ( J:96731 )

• severely impaired glucose tolerance after 5 weeks on a high-fat diet, however food consumption, body weight gain, and tissue weight redistribution on the high-fat diet did not differ from wildtype and had normal glucose tolerance on a standard diet

insulin resistance ( J:96731 )

• significantly decreased insulin sensitivity in an insulin tolerance test