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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smc1btm1Jess
targeted mutation 1, Rolf Jessberger
MGI:3573932
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smc1btm1Jess/Smc1btm1Jess involves: 129S6/SvEvTac * C57BL/6 MGI:3575898
ht2
Smc1btm1Jess/Smc1btm2.2Jess involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4867234
cn3
Smc1btm1Jess/Smc1btm2.1Jess
Tg(Gdf9-icre)5092Coo/0
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4867233


Genotype
MGI:3575898
hm1
Allelic
Composition
Smc1btm1Jess/Smc1btm1Jess
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc1btm1Jess mutation (0 available); any Smc1b mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• seminiferous tubule contain Sertoli cells and spermatogonia but no spermatids
• synaptonemal complexes are shortened, sister chromatid cohesion is impaired, fewer crossover complexes are seen similar to defects seen in male meiosis
• unlike in males, oocytes progress through meiosis I to dictyate arrest, but defective cohesion results in massive aneuploidy during meiotic divisions
• the prophase axial elements are shorter, chromosome synapsis is incomplete, sister chromatid cohesion is lost prematurely, telomere attachment is impaired, and crossover complexes are not seen
• spermatogenesis is arrested by the mid-pachytene stage and increased numbers of apoptotic cells are seen at P17
• at 5 weeks of age mutant testes are about half the weight of wild-type and the weight difference increases with age
• both male and female homozygotes are infertile

endocrine/exocrine glands
• at 5 weeks of age mutant testes are about half the weight of wild-type and the weight difference increases with age

cellular
• seminiferous tubule contain Sertoli cells and spermatogonia but no spermatids
• synaptonemal complexes are shortened, sister chromatid cohesion is impaired, fewer crossover complexes are seen similar to defects seen in male meiosis
• unlike in males, oocytes progress through meiosis I to dictyate arrest, but defective cohesion results in massive aneuploidy during meiotic divisions
• the prophase axial elements are shorter, chromosome synapsis is incomplete, sister chromatid cohesion is lost prematurely, telomere attachment is impaired, and crossover complexes are not seen
• spermatogenesis is arrested by the mid-pachytene stage and increased numbers of apoptotic cells are seen at P17




Genotype
MGI:4867234
ht2
Allelic
Composition
Smc1btm1Jess/Smc1btm2.2Jess
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc1btm1Jess mutation (0 available); any Smc1b mutation (69 available)
Smc1btm2.2Jess mutation (0 available); any Smc1b mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

cellular




Genotype
MGI:4867233
cn3
Allelic
Composition
Smc1btm1Jess/Smc1btm2.1Jess
Tg(Gdf9-icre)5092Coo/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc1btm1Jess mutation (0 available); any Smc1b mutation (69 available)
Smc1btm2.1Jess mutation (0 available); any Smc1b mutation (69 available)
Tg(Gdf9-icre)5092Coo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice are fertile
• aged mice exhibit normal maintenance of sister chromatid cohesion and chiasma position





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory