reproductive system
azoospermia
(
J:96769
)
• seminiferous tubule contain Sertoli cells and spermatogonia but no spermatids
|
• synaptonemal complexes are shortened, sister chromatid cohesion is impaired, fewer crossover complexes are seen similar to defects seen in male meiosis
• unlike in males, oocytes progress through meiosis I to dictyate arrest, but defective cohesion results in massive aneuploidy during meiotic divisions
|
• the prophase axial elements are shorter, chromosome synapsis is incomplete, sister chromatid cohesion is lost prematurely, telomere attachment is impaired, and crossover complexes are not seen
|
• spermatogenesis is arrested by the mid-pachytene stage and increased numbers of apoptotic cells are seen at P17
|
• at 5 weeks of age mutant testes are about half the weight of wild-type and the weight difference increases with age
|
infertility
(
J:96769
)
• both male and female homozygotes are infertile
|
endocrine/exocrine glands
• at 5 weeks of age mutant testes are about half the weight of wild-type and the weight difference increases with age
|
cellular
azoospermia
(
J:96769
)
• seminiferous tubule contain Sertoli cells and spermatogonia but no spermatids
|
• synaptonemal complexes are shortened, sister chromatid cohesion is impaired, fewer crossover complexes are seen similar to defects seen in male meiosis
• unlike in males, oocytes progress through meiosis I to dictyate arrest, but defective cohesion results in massive aneuploidy during meiotic divisions
|
• the prophase axial elements are shorter, chromosome synapsis is incomplete, sister chromatid cohesion is lost prematurely, telomere attachment is impaired, and crossover complexes are not seen
|
• spermatogenesis is arrested by the mid-pachytene stage and increased numbers of apoptotic cells are seen at P17
|