Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Tyr-cre)2Lru transgene insertion 2, Lionel Larue MGI:3573938 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hair pigmentation is even more reduced with complete absence of Notch1 and 2 in melanocytes: hair is almost white
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• hair pigmentation is even more reduced with complete absence of Notch1 and 2 in melanocytes: hair is almost white
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• pigmentation mediated by non-follicular melanocytes such as in the ear or eye is not affected by this mutation
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• when crossed to transgenic mice to visualize melanoblasts and melanocytes (dopachrome tautomerase - LacZ mice), at 9 days of age, a decreased number of melanocytes in the lower permanent portion of the hair follicle is observed; differences are greater at 3 and 4.5 weeks with most follicles lacking melanocytes
• mutant hair bulbs lack pigment after their first regeneration
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• coat is completetly gray with coat slightly lighter in color compared to mice missing both Notch2 alleles and one Notch1 allele
• dilution is progressive and increases with age; there is an increasing number of gray and white hairs with age such that at 7 days coat color is indistinguishable from controls, but at 7 months, coat is completely white
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• when crossed to transgenic mice to visualize melanoblasts and melanocytes (dopachrome tautomerase - LacZ mice), at 9 days of age, a decreased number of melanocytes in the lower permanent portion of the hair follicle is observed; differences are greater at 3 and 4.5 weeks with most follicles lacking melanocytes
• mutant hair bulbs lack pigment after their first regeneration
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• coat is completetly gray with coat slightly lighter in color compared to mice missing both Notch2 alleles and one Notch1 allele
• dilution is progressive and increases with age; there is an increasing number of gray and white hairs with age such that at 7 days coat color is indistinguishable from controls, but at 7 months, coat is completely white
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 weeks, dispersed gray hairs are observed
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• at 8 weeks, dispersed gray hairs are observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dispersed gray hairs are observed, identical to Notch2 mutants or Notch1/Notch2 double heterozygotes, but first gray hairs are only visible at 12 weeks
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• dispersed gray hairs are observed, identical to Notch2 mutants or Notch1/Notch2 double heterozygotes, but first gray hairs are only visible at 12 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• loss of one allele has no affect on coat color; no graying or dilution is observed in 8-week old mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• pigmentation mediated by non-follicular melanocytes such as in the ear or eye is not affected by this mutation
|
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• almost complete hair whitening is observed
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• almost complete hair whitening is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• loss of one allele has no affect on coat color; no graying or dilution is observed in 8-week old mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• pigmentation mediated by non-follicular melanocytes such as in the ear or eye is not affected by this mutation
|
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• coat is completetly gray
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• coat is completetly gray
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 weeks, dispersed gray hairs are observed
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• at 8 weeks, dispersed gray hairs are observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal coat color on the abdomen and extremities, melanocyte stem cells and renewal
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• enlarged, clustered WASH- and WAFL-positive vesicles
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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