Phenotypes associated with this allele

• Allele Symbol: Itgb4^tm2Son
• Allele Name: targeted mutation 2, Arnoud Sonnenberg
• Allele ID: MGI:3573958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Itgb4^tm2Son/Itgb4^tm2Son Tg(KRT14-cre)8Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3574283

Genotype
MGI:3574283

cn1

• Allelic Composition: Itgb4^tm2Son/Itgb4^tm2Son; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

ear inflammation ( J:96543 )

• 16% of adult mutants developed an inflammation of the ear that might have been caused by repeated detachment of the epidermis

hearing/vestibular/ear

ear inflammation ( J:96543 )

• 16% of adult mutants developed an inflammation of the ear that might have been caused by repeated detachment of the epidermis

integument

abnormal keratinocyte morphology ( J:96543 )

• some areas of the skin had basal keratinocytes lacking hemidesmosomes that had detached from the dermis, however the regions of the skin where adhesion of the epidermis to the dermis is not compromised, keratinocytes were normal

blistering ( J:96543 )

• skin from newborn mutants exhibited small blisters in some areas of the epithelium, however organization of the skin, epidermal differentiation, epidermal proliferation, epidermal survival and formation of hair follicles and their epidermal branching was normal