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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gzmbtm2.1Ley
targeted mutation 2.1, Timothy J Ley
MGI:3574017
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gzmbtm2.1Ley/Gzmbtm2.1Ley 129X1/SvJ-Gzmbtm2.1Ley MGI:3577927
cx2
 		Gzmatm1Ley/Gzmatm1Ley
Gzmbtm2.1Ley/Gzmbtm2.1Ley 		involves: 129X1/SvJ MGI:4421421


Genotype
MGI:3577927
hm1
Allelic
Composition		 Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic
Background		 129X1/SvJ-Gzmbtm2.1Ley
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmbtm2.1Ley mutation (1 available); any Gzmb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased cytotoxic T cell cytolysis ( J:96538 )
• using a flow-based killing assay, CTLs from mutant mice showed a less severe cytotoxic defect than CTLs from Gzmbtm2Ley homozygous mice

hematopoietic system
decreased cytotoxic T cell cytolysis ( J:96538 )
• using a flow-based killing assay, CTLs from mutant mice showed a less severe cytotoxic defect than CTLs from Gzmbtm2Ley homozygous mice




Genotype
MGI:4421421
cx2
Allelic
Composition		 Gzmatm1Ley/Gzmatm1Ley
Gzmbtm2.1Ley/Gzmbtm2.1Ley
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmatm1Ley mutation (1 available); any Gzma mutation (34 available)
Gzmbtm2.1Ley mutation (1 available); any Gzmb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:126114 )
• phenotype is stated to be similar to that of Gzmatm1Ley Gzmbtm1Ley double homozygotes, however no data is presented in J:126114




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory