Phenotypes associated with this allele

• Allele Symbol: Trpv3^tm1Apat
• Allele Name: targeted mutation 1, Ardem Patapoutian
• Allele ID: MGI:3574024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpv3^tm1Apat/Trpv3^tm1Apat	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3574328

Genotype
MGI:3574328

hm1

• Allelic Composition: Trpv3^tm1Apat/Trpv3^tm1Apat
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal thermosensation ( J:96549 )

• deficit in sensing warm temperature, with mutants spending less time on a warm surface than wildtype and exhibiting a delay in the time it took to prefer the warm surface, indicating strong deficits in response to innocuous heat, but showed no difference from wildtype in cold sensation

increased thermal nociceptive threshold ( J:96549 )

• observed significant withdrawal latencies in mutants at 55C in a hot plate test

• observed delayed tail flick responses at 50C or above in a tail immersion assay indicating strong deficits in response to noxious heat

integument

abnormal coat/ hair morphology ( J:96549 )

• some homozygous mutants exhibited a subtle and temporary hair irregularity in the abdominal area occurring around the third postnatal week

abnormal keratinocyte physiology ( J:96549 )

• camphor (a compound that leads to sensitization to heat responses), heat or repeated application of campor failed to evoke sensitizing current responses in homozygous mutant keratinocytes but not in wildtype