Phenotypes associated with this allele

• Allele Symbol: Nr2f6^tm1Ge
• Allele Name: targeted mutation 1, Gregor Eichele
• Allele ID: MGI:3574037
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr2f6^tm1Ge/Nr2f6^tm1Ge	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3574281

Genotype
MGI:3574281

hm1

• Allelic Composition: Nr2f6^tm1Ge/Nr2f6^tm1Ge
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal circadian behavior ( J:96328 )

• the ability to adapt to a forward shift in the light dark cycle is impaired and anticipatory locomotor activity in a LD restricted feeding paradigm is significantly reduced

abnormal locomotor circadian rhythm ( J:96328 )

• anticipatory locomotor activity in a LD restricted feeding paradigm is significantly reduced

shortened circadian behavior period ( J:96328 )

• for any given light intensity under constant light conditions the period in mutants was shorter than that in wild-type mice and mutants became arrythmic at lower light intensities

• under constant darkness the endogenous period lengths are not significantly different; however the variability in time of activity onset was greater in mutants

abnormal nociception after inflammation ( J:96328 )

• with artificial inflammation latency to withdrawal was furthered decreased by a factor of 2 when mutants were placed on a hot plate at 44 degrees C (secondary nociception)

abnormal thermal nociception ( J:96328 )

• primary nociception is increased in mutants at all temperatures examined and secondary nociception is increased 3-fold

nervous system

abnormal synaptic norepinephrine release ( J:96328 )

• a 3- to 4-fold decrease in norepinephrine levels is seen in frontal cortical slices

• norepinephrine levels are reduced by 40% in the spinal cord