Analysis Tools
muscle
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• skeletal muscle weight as a proportion of total body weight is similar to wild-type controls
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Allele Symbol Allele Name Allele ID |
Hey1tm1Kkb targeted mutation 1, Hiroki Kokubo MGI:3574059 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• skeletal muscle weight as a proportion of total body weight is similar to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1
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• mutants exhibit ectopic appearance of cell masses in the atrioventricular cushion
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• the interventricular septum is shifted to the right side
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• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: less than 5% of pups on an inbred C57BL/6 (N9) background survive the first 3 weeks of life compared to about 90% of pups on a mixed (N2) background
• survival is better in the N7 generation compared to the F9 generation
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• expression analysis indicates satellite cells are not in an undifferentiated quiescent state in adult skeletal muscle in mice from the N7 generation
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• decrease in muscle weight and muscle weight as a proportion of body weight in mice from the N7 generation compared to littermate controls
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• satellite cells are slightly larger in mice from the N7 generation compared to littermate controls
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• in mice from the N7 generation compared to littermate controls
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• in mice from the N7 generation compared to littermate controls
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• in mice from the N7 generation compared to littermate controls
• gradual decrease in satellite cells with age
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• regeneration following cardiotoxin injection is impaired in mice from the N7 generation
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• slight decrease in body size in mice from the N7 generation compared to littermate controls
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• significant decrease in body weight in mice from the N7 generation compared to littermate controls
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• expression analysis indicates satellite cells are not in an undifferentiated quiescent state in adult skeletal muscle in mice from the N7 generation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double homozygotes die by E11.5
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• the cell layers surrounding the arteries are thinner
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• the putative dorsal aorta lacks expression of smooth muscle actin and Ephrin-B2 suggesting failure of arterial differentiation
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• the putative dorsal aorta lacks expression of smooth muscle actin and Ephrin-B2 suggesting failure of arterial differentiation
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• the cardiomyocytes are disorganized with fewer myofibrils and swollen and irregular mitochondria
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• the trabecular zone is not properly formed at E10.5
• hypoplastic trabeculae are seen in the single open atria and ventricle
• initial formation of the trabecular zone is normal however more apoptotic cells are seen compared to double heterozygous littermates at E10
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• at E9.5 cardiac endothelial cell transformation does not occur in the AV cushion despite enrichment of the extracellular matrix
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• the heart chambers fails to divide resulting in a single atria and ventricles at E10.5
• however, right-left polarity is established
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• the AV cushions are not properly formed at E10.5
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• only a single atria is present at E10.5
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• only a single ventricle is present at E10.5
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• seen at E10.5
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• the first pharyngeal arches are smaller at E10.5
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• the second pharyngeal arches are smaller at E10.5
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• at E10.5 large blood vessels fail to form in the yolk sac; however, small blood vessels are present
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• the cardiomyocytes are disorganized with fewer myofibrils and swollen and irregular mitochondria
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• the trabecular zone is not properly formed at E10.5
• hypoplastic trabeculae are seen in the single open atria and ventricle
• initial formation of the trabecular zone is normal however more apoptotic cells are seen compared to double heterozygous littermates at E10
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• at E10.5 the telencephalic regions are poorly formed
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• the first pharyngeal arches are smaller at E10.5
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• the second pharyngeal arches are smaller at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: about 90% of pups survive the first 3 weeks of life on a mixed (N2) background compared to less than 5% of pups on an inbred C57BL/6 (N9) background
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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