Analysis Tools
hematopoietic system
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• greatly increased numbers of megakaryocytes in bone marrow
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• 2- to 10- fold decrease in splenocyte and thymocyte count
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• both megakaryocyte/erythrocyte progenitor cells and hematopoietic stem cells from mutant mice showed reductions in the number of red blood cell colony formation in vitro assay
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• have block at the pro- to pre-B cell transition
• however, the few mutant B cells that progressed beyond this transition can mature normally
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• 3-fold reductions in the number of both DN1 and DN4 cells in mature animals
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• there was no increased number of cycling cells in mutant mice
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• had normal levels of most myeloid cell populations (neutrophils, monocytes, and basophils), but eosinophils are absent
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macrocytosis
(
J:96507
)
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• red blood cells larger in size compared to normal litter mates
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• elevated levels of platelets in the peripheral blood
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• larger in size compared to normal litter mates
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• decreased B220+ B cells
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• decreased CD4+ or CD8+ T cells
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• number of phenotypic hematopoietic stem cells in bone marrow was increased 5- to 10-fold
• competitive bone marrow transplantation experiments showed that mutant mice contain 10-fold elevation in the number of long-term hematopoietic stem cells
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immune system
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• 2- to 10- fold decrease in splenocyte and thymocyte count
|
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• have block at the pro- to pre-B cell transition
• however, the few mutant B cells that progressed beyond this transition can mature normally
|
|
• 3-fold reductions in the number of both DN1 and DN4 cells in mature animals
|
|
• had normal levels of most myeloid cell populations (neutrophils, monocytes, and basophils), but eosinophils are absent
|
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• decreased B220+ B cells
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• decreased CD4+ or CD8+ T cells
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cellular
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• greatly increased numbers of megakaryocytes in bone marrow
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endocrine/exocrine glands
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• 2- to 10- fold decrease in splenocyte and thymocyte count
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