All Phenotypes Akt3<tm1Mbb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt3^tm1Mbb
targeted mutation 1, Morris J Birnbaum
MGI:3574346

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt3^tm1Mbb/Akt3^tm1Mbb	B6.Cg-Akt3^tm1Mbb	MGI:6316993
hm2	Akt3^tm1Mbb/Akt3^tm1Mbb	involves: C57BL/6J	MGI:4941198
hm3	Akt3^tm1Mbb/Akt3^tm1Mbb	Not Specified	MGI:3574757
ht4	Akt3^tm1Mbb/Akt3⁺	B6.Cg-Akt3^tm1Mbb	MGI:6316994
cn5	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd	MGI:3803972
cn6	Akt1^tm1Pnt/Akt1^tm1Pnt Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0	Not Specified	MGI:3803970
cx7	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804003
cx8	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-PyVT)634Mul/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804008
cx9	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb	involves: 129P2/OlaHsd	MGI:3803968

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	B6.Cg-Akt3^tm1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired discrimination learning ( J:245549 )

• mice exhibit impaired temporal order object discrimination memory

• however, novel object preference is normal, sensorimotor gating is normal, learned fear conditioning and fear extinction are intact, and social functioning is normal

abnormal spatial reference memory ( J:245549 )

• mice exhibit impaired spatial location memory

increased locomotor activity ( J:245549 )

• baseline locomotor activity is increased, with mice being hyperactive and traveling significantly more distance in the border

• however, mice do not show increased anxiety

nervous system

decreased brain size ( J:245549 )

• 24% reduction in brain size

• however, body weight and size is normal

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit higher electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

nervous system

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit higher electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:96823 )

N	• no abnormalities in carbohydrate metabolism

nervous system

decreased brain size ( J:96823 )

• adult brains were 25% smaller than in wildtype, however body size and other organ sizes were normal

• postnatal day 1 homozgyotes displayed a 15% reduction in brain size

• the relative reduction in brain size compared to wildtype continued to increase during the first 3 weeks of life, reaching the same degree as that seen in adults by the end of the third week

• decrease in cell number and a reduction in cell size in the brain

immune system

immune system phenotype ( J:135903 )

N	• no abnormalities in T cell development are observed

Allelic Composition	Akt3^tm1Mbb/Akt3⁺
Genetic Background	B6.Cg-Akt3^tm1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain size ( J:245549 )

• 7% reduction in brain size

Allelic Composition	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Pnt mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (53 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

immune system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

cellular

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

Allelic Composition	Akt1^tm1Pnt/Akt1^tm1Pnt Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Pnt mutation (0 available); any Akt1 mutation (34 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 2.5 fold

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 78.2% compared to 84.6% in wild-type mice

immune system

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 2.5 fold

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 78.2% compared to 84.6% in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 2.5 fold

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 17.5 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 17.5 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 17.5 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (53 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:135903 )

• no abnormalities in T cell development are observed

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