Analysis Tools
mortality/aging
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• the expected Mendelian ratio of null mice was present on the day preceding birth but only 55% remained on the day after birth
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• of those surviving after day 1, most survived to adulthood with 40% surviving at time of weaning
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renal/urinary system
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• on the day following birth, pups showed a shrinkage of both layers of the kidney and an enlarged caliceal space, however kidneys were normal at E18.5
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• a reduction of cortical width is seen on the day after birth
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• a reduction of medullary width is seen on the day after birth
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• on the day following birth, pups displayed an enlarged caliceal space
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reproductive system
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• release of oocytes from the follicles was reduced by 70% resulting in a decreased number of oocytes in the oviducts and the number of implantation sites was reduced by 43%, however females have a normal uterus and estrous cycle
• several oocytes were found to be trapped in the corpora lutea after ovulation
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• 38% of females give birth to pups after plug formation
• the pregnancy rate was decreased during gestation at a greater rate (83% at E4.5 to 50% at E15.5) compared with wildtype (100% at E4.5 to 83% at E15.5), suggesting a loss of embryos as pregnancy progressed
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