Analysis Tools|
Allele Symbol Allele Name Allele ID |
Txnrd1tm1Marc targeted mutation 1, Marcus Conrad MGI:3574358 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• cerebellar foliation is normal
|
| N |
• mice exhibit normal behavior
|
| N |
• mice exhibit normal growth
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• most regions of the brain including the olfactory bulb, subventricular zone and cerebral cortex are morphologically normal
|
|
• fissure formation in the anterior cerebellum is reduced
|
|
• only lobules VII to X form, while lobules I to VI are fused and unlaminated
|
|
• from P1
|
|
• there is no distinction between the molecular, Purkinje cell and granular layers in the anterior portions of the cerebellar cortex
• however, lamination of the posterior cerebellar cortex is normal
|
|
• the dendritic trees of Purkinje cells, in the anterior more so than the posterior cerebellum, are less elaborate than in wild-type mice
|
|
• at weaning the cerebellum is one fourth of wild-type in size
• cell proliferation is 3 times lower than normal at P7 and 2 times lower than normal at P14
• cell density in the granular layer in the anterior end is reduced
the posterior lobules are smaller
• however, apoptotic rates are normal
|
|
• glial cells in the anterior cerebellum are disoriented
|
|
• Bergmann glial fibers in the anterior cerebellum are shorter, disoriented and reduced in density compared to in wild-type mice
|
|
• at P7
|
|
• 11 of 14 times mice fail to climb down a pole in a modified pole test unlike wild-type mice
|
|
• at P7, mice exhibit an ataxic gait
|
|
• although of normal size at birth, within a few days mice are smaller than wild-type mice
|
|
• by 4 weeks of age mice have only reached half the weight of wild-type mice
• mice only grow to adulthood when provided food pellets at the bottom of the cage
|
| N |
• mice are fertile and able to nurse
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no differences in heart shape or in the cellular morphology of cardiomyocytes
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
