Phenotypes associated with this allele

• Allele Symbol: Corin^tm1Qwu
• Allele Name: targeted mutation 1, Qingyu Wu
• Allele ID: MGI:3574359
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Corin^tm1Qwu/Corin^tm1Qwu	involves: 129X1/SvJ * C57BL/6	MGI:3574374

Genotype
MGI:3574374

hm1

• Allelic Composition: Corin^tm1Qwu/Corin^tm1Qwu
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:96458 )

• in younger male animals (12 weeks) two-dimensional transthoracic echocardiography showed increased left ventricular mass

• in older male animals (>14 months) whole heart and individual chamber weights, indexed to tibia length, showed increased left ventricular mass and increased right ventricular weight

decreased cardiac muscle contractility ( J:96458 )

• at 35 weeks of age, significant decreases in percent fractional shortening are seen by two-dimensional transthoracic echocardiography

hypertension ( J:96458 )

• increases in mean arterial pressure resulting from increases in both systolic blood pressure and diastolic blood pressure on normal diet

salt-sensitive hypertension ( J:96458 )

• systolic blood pressure is further elevated with dietary salt loading

increased systemic arterial systolic blood pressure ( J:96458 )

• systolic blood pressure is further elevated with dietary salt loading

• systolic blood pressure was also further increased in mutant mice during pregnancy

growth/size/body

cardiac hypertrophy ( J:96458 )

• in younger male animals (12 weeks) two-dimensional transthoracic echocardiography showed increased left ventricular mass

• in older male animals (>14 months) whole heart and individual chamber weights, indexed to tibia length, showed increased left ventricular mass and increased right ventricular weight

increased body weight ( J:96458 )

• beginning at 15 weeks in females and 20 weeks in males

homeostasis/metabolism

increased urine protein level ( J:96458 )

• at late gestation stages during pregnancy

muscle

decreased cardiac muscle contractility ( J:96458 )

• at 35 weeks of age, significant decreases in percent fractional shortening are seen by two-dimensional transthoracic echocardiography

renal/urinary system

increased urine protein level ( J:96458 )

• at late gestation stages during pregnancy