Analysis Tools|
Allele Symbol Allele Name Allele ID |
Phb2tm1Katz targeted mutation 1, Benita S Katzenellenbogen MGI:3574361 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation
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• females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight
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• exhibited smaller litter sizes than on a mixed 129S6/SvEvTac and C57BL/6 background
• litter size of the second-generation mice were reduced significantly from those of the first-generation mice (4.1 vs 6.1 pups)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the numbers of heterozygous mutants were underrepresented among weaned pups but did not observe death after birth, indicating that some embryos may have died during a late gestational stage
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• heterozygous females exhibited a greater gain in body weight from 9 weeks of age to 26 weeks of age than in wildtype, but no differences in males
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• the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation
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• females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight
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• exhibited larger litter sizes than on the 129S6/SvEvTac coisogenic background
• litter sizes of second-generation mice were reduced significantly from those of the first-generation mice (5.9 vs 7.5 pups)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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