Phenotypes associated with this allele

• Allele Symbol: Txnip^tm1Yu
• Allele Name: targeted mutation 1, Dae-Yeul Yu
• Allele ID: MGI:3574362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Txnip^tm1Yu/Txnip^tm1Yu	involves: 129	MGI:3575886

Genotype
MGI:3575886

hm1

• Allelic Composition: Txnip^tm1Yu/Txnip^tm1Yu
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal ileum morphology ( J:96677 )

• diffuse hyperplasia of the lymphoid tissue containing a large germinal center is seen in the ileum in 4- to 6-month old mutants

• NK cell numbers are reduced in the lamina propria of the ileum

hematopoietic system

increased T cell proliferation ( J:96677 )

• proliferation of splenic T cells is increased in the presence of IL-2

• proliferation of thymocytes and splenocytes is increased in the presence of PMA plus ionomycin or anti-CD3 plus anti-CD28 compared to wild-type littermates

decreased CD8-positive, alpha-beta T cell number ( J:96677 )

• the number of CD8+ cells in the spleen and lymph node is reduced by about 40%

• however, thymic cellularity and T cell populations are normal

decreased NK T cell number ( J:96677 )

• the number of natural killer T cells in the spleen, bone marrow, and lung are reduced

increased lymphocyte cell number ( J:96677 )

• the number of intestinal intraepithelial lymphocytes and lamina propria lymphocytes were increased 4- and 4.7-fold, respectively

increased regulatory T cell number ( J:96677 )

• the percentage of CD4+CD25+ regulatory T cells is increased about 2-fold in the lymph nodes but not in the spleen

abnormal NK cell morphology ( J:96677 )

• natural killer cell maturation is impaired in the spleen

decreased NK cell number ( J:96677 )

• the number of natural killer cells in the spleen, bone marrow, and lung are reduced; however the percentage of CD3+ T cells is not significantly different from wild-type

• the number of precursor and mature natural killer cells differentiated from hematopoietic stem cells in vitro is reduced

abnormal NK cell physiology ( J:96677 )

• mutant mice reject RMA-S tumor cells less efficiently

• natural killer cell activity is impaired in the spleen

immune system

increased T cell proliferation ( J:96677 )

• proliferation of splenic T cells is increased in the presence of IL-2

• proliferation of thymocytes and splenocytes is increased in the presence of PMA plus ionomycin or anti-CD3 plus anti-CD28 compared to wild-type littermates

decreased CD8-positive, alpha-beta T cell number ( J:96677 )

• the number of CD8+ cells in the spleen and lymph node is reduced by about 40%

• however, thymic cellularity and T cell populations are normal

decreased NK T cell number ( J:96677 )

• the number of natural killer T cells in the spleen, bone marrow, and lung are reduced

increased lymphocyte cell number ( J:96677 )

• the number of intestinal intraepithelial lymphocytes and lamina propria lymphocytes were increased 4- and 4.7-fold, respectively

increased regulatory T cell number ( J:96677 )

• the percentage of CD4+CD25+ regulatory T cells is increased about 2-fold in the lymph nodes but not in the spleen

abnormal NK cell morphology ( J:96677 )

• natural killer cell maturation is impaired in the spleen

decreased NK cell number ( J:96677 )

• the number of natural killer cells in the spleen, bone marrow, and lung are reduced; however the percentage of CD3+ T cells is not significantly different from wild-type

• the number of precursor and mature natural killer cells differentiated from hematopoietic stem cells in vitro is reduced

abnormal NK cell physiology ( J:96677 )

• mutant mice reject RMA-S tumor cells less efficiently

• natural killer cell activity is impaired in the spleen

abnormal mesenteric lymph node morphology ( J:96677 )

• diffuse hyperplasia of the lymphoid tissue containing a large germinal center is seen in the ileum in 4- to 6-month old mutants

cellular

increased T cell proliferation ( J:96677 )

• proliferation of splenic T cells is increased in the presence of IL-2

• proliferation of thymocytes and splenocytes is increased in the presence of PMA plus ionomycin or anti-CD3 plus anti-CD28 compared to wild-type littermates