About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		IghdeltaD
delta D, Rudolf Jaenisch
MGI:3574367
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		IghdeltaD/IghdeltaD involves: C57BL/6 * DBA/2 MGI:3575925
ht2
 		IghdeltaD/Igh+ involves: C57BL/6 * DBA/2 MGI:3575926
ht3
 		IghdeltaD/Ightm11.1Cgn involves: C57BL/6 * DBA/2 MGI:3687971


Genotype
MGI:3575925
hm1
Allelic
Composition		 IghdeltaD/IghdeltaD
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
IghdeltaD mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:95981 )
• B cell progenitors blocked at the pro- to pre-B cell transition
decreased B cell number ( J:95981 )
• reduced numbers of B cells, about 34 fold at 5 weeks and 7 fold at 6 months of age
decreased follicular B cell number ( J:95981 )
• follicular B cells more reduced than marginal zone B cells
increased marginal zone B cell number ( J:95981 )
• marginal zone B cells increase 7 fold between 5 and 25 weeks of age as opposed to a 3 fold increase in controls
increased IgA level ( J:95981 )
• IgA levels were 2X those found in heterozygotes
decreased IgG1 level ( J:95981 )
• IgG1 levels were reduced 5 fold from levels in heterozygotes

immune system
arrested B cell differentiation ( J:95981 )
• B cell progenitors blocked at the pro- to pre-B cell transition
decreased B cell number ( J:95981 )
• reduced numbers of B cells, about 34 fold at 5 weeks and 7 fold at 6 months of age
decreased follicular B cell number ( J:95981 )
• follicular B cells more reduced than marginal zone B cells
increased marginal zone B cell number ( J:95981 )
• marginal zone B cells increase 7 fold between 5 and 25 weeks of age as opposed to a 3 fold increase in controls
increased IgA level ( J:95981 )
• IgA levels were 2X those found in heterozygotes
decreased IgG1 level ( J:95981 )
• IgG1 levels were reduced 5 fold from levels in heterozygotes




Genotype
MGI:3575926
ht2
Allelic
Composition		 IghdeltaD/Igh+
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
IghdeltaD mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:95981 )
• few, if any, B cells formed using mutant allele
decreased immunoglobulin level ( J:95981 )
• little, if any, antibody formed using the mutant allele

immune system
decreased B cell number ( J:95981 )
• few, if any, B cells formed using mutant allele
decreased immunoglobulin level ( J:95981 )
• little, if any, antibody formed using the mutant allele




Genotype
MGI:3687971
ht3
Allelic
Composition		 IghdeltaD/Ightm11.1Cgn
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
IghdeltaD mutation (0 available); any Igh mutation (44 available)
Ightm11.1Cgn mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:113434 )
• analysis shows that VH replacement contributes more or is more frequent direct VH to DH joining in determining IgH chain repertoire

hematopoietic system
abnormal B cell differentiation ( J:113434 )
• analysis shows that VH replacement contributes more or is more frequent direct VH to DH joining in determining IgH chain repertoire




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory