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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adad1tm1Reb
targeted mutation 1, Robert E Braun
MGI:3574372
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adad1tm1Reb/Adad1tm1Reb 129X1/SvJ-Tenrtm1Reb MGI:3574640
hm2
 		Adad1tm1Reb/Adad1tm1Reb involves: 129X1/SvJ * C57BL/6 MGI:3574641


Genotype
MGI:3574640
hm1
Allelic
Composition		 Adad1tm1Reb/Adad1tm1Reb
Genetic
Background		 129X1/SvJ-Tenrtm1Reb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adad1tm1Reb mutation (0 available); any Adad1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:96477 )
• a reduction of approximately 6.3- fold in the number of sperm in the epididymis
• considerable retention of differentiated spermatids in seminiferous tubules
teratozoospermia ( J:96477 )
• approximately 81% of epididymal sperm show morphological defects
asthenozoospermia ( J:96477 )
• the percentage of motile sperm was reduced
• motility in sperm that were motile was sluggish
male infertility ( J:96477 )
• the presence of copulation plugs are noted
impaired fertilization ( J:96477 )
• in an in vitro fertilization assay, normal-appearing mutant sperm can bind to zona pellucida-intact oocytes, but fertilization is greatly reduced
• can fertilize zona pellucida-free oocytes

cellular
oligozoospermia ( J:96477 )
• a reduction of approximately 6.3- fold in the number of sperm in the epididymis
• considerable retention of differentiated spermatids in seminiferous tubules
teratozoospermia ( J:96477 )
• approximately 81% of epididymal sperm show morphological defects
asthenozoospermia ( J:96477 )
• the percentage of motile sperm was reduced
• motility in sperm that were motile was sluggish




Genotype
MGI:3574641
hm2
Allelic
Composition		 Adad1tm1Reb/Adad1tm1Reb
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adad1tm1Reb mutation (0 available); any Adad1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
male infertility ( J:96477 )
• males are infertile when backcrossed 4 times to C57BL/6; however, males on a mixed 129X1/SvJ and C57BL/6 background were fertile with litter sizes similar to wild-type control litter mates




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory