Phenotypes associated with this allele

• Allele Symbol: Septin4^tm1Ksh
• Allele Name: targeted mutation 1, Makoto Kinoshita
• Allele ID: MGI:3574373
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Septin4^tm1Ksh/Septin4^tm1Ksh	involves: 129X1/SvJ * C57BL/6J	MGI:3574458

Genotype
MGI:3574458

hm1

• Allelic Composition: Septin4^tm1Ksh/Septin4^tm1Ksh
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

absent sperm annulus ( J:96670 )

♂ • spermatozoa exhibited defective cortical organization with an absent annulus that is replaced by a fragile segment lacking cortical material, beneath which kinesin-mediated intraflagellar transport stalls

abnormal sperm fibrous sheath morphology ( J:96670 )

♂ • the fibrous sheath often failed to cover a proximal segment of the sperm principal piece

kinked sperm flagellum ( J:96670 )

♂ • spermatozoa were sharply bent or broken in the region which separates the middle and principle pieces; however, caput spermatozoa were normal

male infertility ( J:96670 )

♂ • homozygous null males were completely sterile, however seminal vesicles, protates, testes and epididymides were normal

abnormal sperm physiology ( J:96670 )

♂ • low ATP consumption by spermatozoa from the caudate epididymis as they contained much more ATP than wildtype

asthenozoospermia ( J:96670 )

♂ • more than 90% of spermatozoa were either completely immotile or exhibited impaired flagellar movement

cellular

absent sperm annulus ( J:96670 )

♂ • spermatozoa exhibited defective cortical organization with an absent annulus that is replaced by a fragile segment lacking cortical material, beneath which kinesin-mediated intraflagellar transport stalls

abnormal sperm fibrous sheath morphology ( J:96670 )

♂ • the fibrous sheath often failed to cover a proximal segment of the sperm principal piece

kinked sperm flagellum ( J:96670 )

♂ • spermatozoa were sharply bent or broken in the region which separates the middle and principle pieces; however, caput spermatozoa were normal

asthenozoospermia ( J:96670 )

♂ • more than 90% of spermatozoa were either completely immotile or exhibited impaired flagellar movement