Analysis Tools
mortality/aging
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• homozygotes are not found at birth but are present at E9.5
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embryo
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• neural crest cells show impaired delamination and migration
• at E10.5 neural crest cells remain compacted at the base of the branchial arches
• in neural tube explants most mutant neural crest cells migrate at most 10 um compared to wild-type neural crest cells that migrate 80-100 um
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• neural crest cells show impaired delamination
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• seen at E10.5; however, size is similar at E9.5
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• cranial mesenchyme is absent
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• neural plate formation is normal but development is impaired
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• at E10.5 the neural tube is jagged and severely distorted
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• the neuroectoderm remains very thin compared to wild-type littermates
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• at E10.5 failure of neural tube closure is seen along the whole body axis
(J:96452)
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• the somites are misaligned and staggered in a zipper-like fashion
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• the boundaries between somites are not well defined
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growth/size/body
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• seen at E10.5; however, size is similar at E9.5
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• cranial mesenchyme is absent
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vision/eye
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• at E10.5 only rudimentary eye anlagen is seen
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nervous system
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• neural plate formation is normal but development is impaired
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• at E10.5 the neural tube is jagged and severely distorted
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• the neuroectoderm remains very thin compared to wild-type littermates
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• at E10.5 failure of neural tube closure is seen along the whole body axis
(J:96452)
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exencephaly
(
J:194042
)
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• neuroectoderm proliferation is decreased and mitotically active cells are found clustered suggesting a scattering defect after cell division
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cardiovascular system
cellular
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• neural crest cells show impaired delamination and migration
• at E10.5 neural crest cells remain compacted at the base of the branchial arches
• in neural tube explants most mutant neural crest cells migrate at most 10 um compared to wild-type neural crest cells that migrate 80-100 um
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• neural crest cells show impaired delamination
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