All Phenotypes Igh<tm1(Myc)Janz> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm1(Myc)Janz/Igh⁺	involves: 129X1/SvJ * C57BL/6	MGI:3575899
cx2	Igh^tm1(Myc)Janz/Igh⁺ Mdm4^tm1.1Wahl/Mdm4^tm1.1Wahl	involves: 129S/Sv * C57BL/6	MGI:3850671
cx3	Igh^tm1(Myc)Janz/Igh⁺ Tg(Emu-FGFR3)A5Wmk/0	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:4819006
cx4	Igh^tm1(Myc)Janz/Igh⁺ Tg(Emu-FGFR3)D3Wmk/0	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:4819007

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:160845 )

• tumors are more differentiated than tumors from Igh^tm1(Myc)Janz Tg(Emu-FGFR3)A5Wmk or Tg(Emu-FGFR3)D3Wmk heterozygotes

increased tumor incidence ( J:96785 , J:160845 )

• tumor incidence was 68% at 21 months of age (J:96785)

• 75% of mice developed tumors at a median age of 281 days unlike wild-type mice (J:160845)

increased B cell derived lymphoma incidence ( J:96785 , J:160845 )

• most prevalent tumors were lymphoblastic B cell lymphomas with a Burkitt-like 'starry sky' morphology due to tingible body macrophages (J:96785)

• 1/4 of lymphomas were diffuse large B cell lymphomas (J:96785)

• lymphoblastic B-cell lymphomas contain clonal cytogenetic aberrations (J:96785)

increased plasmacytoma incidence ( J:96785 , J:160845 )

• 1/5 of lymphomas were CD19⁺CD138⁺ plasmacytomas that exhibited varying degrees of differentiation, including plasmablastic, anaplastic, and plasmacytic variants (J:96785)

• 25% of tumor exhibit plasmacytoid differentiation (J:160845)

immune system

increased B cell apoptosis ( J:96785 )

• elevated apoptosis in B cells of 4- to 6-month old tumor-free mutants

increased B cell proliferation ( J:96785 )

• B cells proliferated, on average, 3.8 times faster than controls and showed a 3.5-fold increase in the number of cells in S phase of the cell cycle in 4- to 6-month old, tumor-free mutants

• B splenocytes proliferated more vigorously than controls after stimulation with LPS

enlarged spleen ( J:96785 )

• spleen was enlarged in 4- to 6-month old tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

enlarged lymph nodes ( J:96785 )

• lymph nodes were enlarged in 4- to 6-month tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

lymphoid hyperplasia ( J:96785 )

• observed in 4- to 6-month old tumor-free mutants

hematopoietic system

increased B cell apoptosis ( J:96785 )

• elevated apoptosis in B cells of 4- to 6-month old tumor-free mutants

increased B cell proliferation ( J:96785 )

• B cells proliferated, on average, 3.8 times faster than controls and showed a 3.5-fold increase in the number of cells in S phase of the cell cycle in 4- to 6-month old, tumor-free mutants

• B splenocytes proliferated more vigorously than controls after stimulation with LPS

enlarged spleen ( J:96785 )

• spleen was enlarged in 4- to 6-month old tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

cellular

increased B cell apoptosis ( J:96785 )

• elevated apoptosis in B cells of 4- to 6-month old tumor-free mutants

increased B cell proliferation ( J:96785 )

• B cells proliferated, on average, 3.8 times faster than controls and showed a 3.5-fold increase in the number of cells in S phase of the cell cycle in 4- to 6-month old, tumor-free mutants

• B splenocytes proliferated more vigorously than controls after stimulation with LPS

growth/size/body

enlarged spleen ( J:96785 )

• spleen was enlarged in 4- to 6-month old tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:96785

Allelic Composition	Igh^tm1(Myc)Janz/Igh⁺ Mdm4^tm1.1Wahl/Mdm4^tm1.1Wahl
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1(Myc)Janz mutation (2 available); any Igh mutation (44 available)
Mdm4^tm1.1Wahl mutation (0 available); any Mdm4 mutation (193 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:150341 )

• mice exhibit increased premature lethality compared with Igh^tm1Janz heterozygotes

immune system

increased splenocyte proliferation ( J:150341 )

enlarged spleen ( J:150341 )

enlarged lymph nodes ( J:150341 )

neoplasm

increased lymphoma incidence ( J:150341 )

• lymphomagenesis is accelerated compared to in Igh^tm1Janz heterozygotes

increased B cell derived lymphoma incidence ( J:150341 )

hematopoietic system

increased splenocyte proliferation ( J:150341 )

enlarged spleen ( J:150341 )

liver/biliary system

enlarged liver ( J:150341 )

cellular

increased splenocyte proliferation ( J:150341 )

growth/size/body

enlarged liver ( J:150341 )

enlarged spleen ( J:150341 )

Allelic Composition	Igh^tm1(Myc)Janz/Igh⁺ Tg(Emu-FGFR3)A5Wmk/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1(Myc)Janz mutation (2 available); any Igh mutation (44 available)
Tg(Emu-FGFR3)A5Wmk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:160845 )

• tumors are less differentiated than tumors from Igh^tm1(Myc)Janz heterozygotes

increased tumor incidence ( J:160845 )

• 98% of mice developed tumors at a median age of 156 days unlike wild-type mice

increased B cell derived lymphoma incidence ( J:160845 )

increased plasmacytoma incidence ( J:160845 )

• 1 tumor exhibits plasmacytoid differentiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple myeloma		DOID:9538	OMIM:254500	J:160845

Allelic Composition	Igh^tm1(Myc)Janz/Igh⁺ Tg(Emu-FGFR3)D3Wmk/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1(Myc)Janz mutation (2 available); any Igh mutation (44 available)
Tg(Emu-FGFR3)D3Wmk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:160845 )

• tumors are less differentiated than tumors from Igh^tm1(Myc)Janz heterozygotes

increased tumor incidence ( J:160845 )

• 98% of mice developed tumors at a median age of 156 days unlike wild-type mice

increased B cell derived lymphoma incidence ( J:160845 )

increased plasmacytoma incidence ( J:160845 )

• 1 tumor exhibits plasmacytoid differentiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple myeloma		DOID:9538	OMIM:254500	J:160845

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24