All Phenotypes Spry1<tm1.1Jdli> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spry1^tm1.1Jdli
targeted mutation 1.1, Jonathan D Licht
MGI:3574404

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spry1^tm1.1Jdli/Spry1^tm1.1Jdli	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:3574645
cn2	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467305
cn3	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467304
cn4	Gdnf^{tm1(cre/ERT2)Cos}/Gdnf⁺ Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺ Spry1^tm1.1Jdli/Spry1⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:5553081
cx5	Itga8^tm1Lfr/Itga8^tm1Lfr Spry1^tm1.1Jdli/Spry1^tm1.1Jdli	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3715486
cx6	Itga8^tm1Lfr/Itga8^tm1Lfr Spry1^tm1.1Jdli/Spry1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3715487
cx7	Gdnf^tm1Bbd/Gdnf⁺ Spry1^tm1.1Jdli/Spry1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5553082
cx8	Gdnf^tm2Bbd/Gdnf⁺ Spry1^tm1.1Jdli/Spry1^tm1.1Jdli	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N	MGI:3574646

Allelic Composition	Spry1^tm1.1Jdli/Spry1^tm1.1Jdli
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:96485 )

• 71% of homozygotes die within 5 months of birth

postnatal lethality, incomplete penetrance ( J:96485 )

• 21% of homozygotes die within 48 hours of birth

renal/urinary system

abnormal kidney morphology ( J:96485 )

• neonatal kidneys are disorganized

kidney cyst ( J:96485 )

• multiple epithelial cysts derived from the collecting system of the kidney

abnormal nephrogenic zone morphology ( J:96485 )

• the nephrogenic zone is not limited to the cortex in newborn mutants

fused kidneys ( J:96485 )

• what appears as a single kidney macroscopically is actually several kidney primordia fused together

abnormal ureter morphology ( J:96485 )

• 20 of 21 homozygotes examined shortly after birth display ureter abnormalities (multiple ureters or hydoureter)

• abnormal ureters end blindly in females and attach to the vas deferens in males

abnormal ureter development ( J:96485 )

• at E14.5, the supernumerary, abnormal ureters remain attached to the Wolffian duct and fail to insert into the bladder

blind ureter ( J:96485 )

• abnormal ureters end blindly in females

ectopic ureter ( J:96485 )

• abnormal ureters attach to the vas deferens in newborn males

hydroureter ( J:96485 )

abnormal ureteric bud morphology ( J:96485 )

• at E11, the ureteric bud is abnormally wide

abnormal branching involved in ureteric bud morphogenesis ( J:96485 )

• in E11.5 kidney explants cultured in vitro, some kidneys display multiple ureteric stalks attached to the Wolffian duct, each of which has undergone branching morphogenesis that results in abnormally wide, and occasionally fused UB tips

abnormal ureteric bud tip morphology ( J:96485 )

• at E11.5, the ureteric bud formed at the normal position has abnormally wide branched tips

abnormal ureteric bud trunk morphology ( J:96485 )

• at E11.5, the ureteric bud formed at the normal position has an abnormally wide stalk

ectopic ureteric bud ( J:96485 )

• at E11, supernumerary buds are seen along the Wolffian duct

• at E11.5, ectopic buds are seen anterior to the wide bud

growth/size/body

kidney cyst ( J:96485 )

• multiple epithelial cysts derived from the collecting system of the kidney

Allelic Composition	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (88 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:192348 )

• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN

reproductive system

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:192348

Allelic Composition	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (16 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

reproductive system

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

Allelic Composition	Gdnf^{tm1(cre/ERT2)Cos}/Gdnf⁺ Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺ Spry1^tm1.1Jdli/Spry1⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^{tm1(cre/ERT2)Cos} mutation (1 available); any Gdnf mutation (19 available)
Gt(ROSA)26Sor^tm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

small kidney ( J:206853 )

• with tamoxifen treatment at E12.5, presence of a single copy of Spry1 only marginally improves the hypoplasia observed at E19.5

Allelic Composition	Itga8^tm1Lfr/Itga8^tm1Lfr Spry1^tm1.1Jdli/Spry1^tm1.1Jdli
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga8^tm1Lfr mutation (2 available); any Itga8 mutation (75 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:122519 )

N	• no kidney agenesis is observed

Allelic Composition	Itga8^tm1Lfr/Itga8^tm1Lfr Spry1^tm1.1Jdli/Spry1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

absent kidney ( J:122519 )

• 25% kidney agenesis incidence

Allelic Composition	Gdnf^tm1Bbd/Gdnf⁺ Spry1^tm1.1Jdli/Spry1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Bbd mutation (0 available); any Gdnf mutation (19 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:206853 )

N	• at E19.5, double heterozygous animals show full rescue of the renal hypoplasia seen in Gdnf^tm1Bbd heterozygotes

Allelic Composition	Gdnf^tm2Bbd/Gdnf⁺ Spry1^tm1.1Jdli/Spry1^tm1.1Jdli
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm2Bbd mutation (0 available); any Gdnf mutation (19 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:96485 )

• only 25% (4 of 16) mice exhibit abnormal kidney development versus about 92% (12 of 13) littermates homozygous Spry1^tm1.1Jdli alone, indicating a ~75% reduction in the occurrence of kidney and urinary tract defects (CAKUT)

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