Analysis Tools
mortality/aging
growth/size/body
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• 33% of mice are smaller than wild-type mice (4.8g compared to 8.4g at day 14)
|
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• small mice die within 20 days of birth
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digestive/alimentary system
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• digestive tract is about half the length of that in wild-type mice
|
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• villi epithelial cells are irregular and the cytoplasm of individual cells is smaller than in wild-type mice
• enterocyte differentiation is defective
• migration of intestinal epithelial cells is defective
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small stomach
(
J:96666
)
respiratory system
|
• distal air spaces are enlarged
• more blood cells are found within the lungs than in wild-type mice
|
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• fewer septa are present
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skeleton
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• chondrocyte proliferation is reduced
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• the resting zone is enlarged
• however, proliferative and hypertropic zones are comparable to those in wild-type mice
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• more blood cells are found within bones compared to in wild-type bones
• bones are thinner than wild-type bones
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hematopoietic system
small spleen
(
J:96666
)
cellular
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• migration of intestinal epithelial cells is defective
|
|
• chondrocyte proliferation is reduced
|
immune system
small spleen
(
J:96666
)
