All Phenotypes Prkdc<dxnph> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prkdc^dxnph
doxorubicin nephropathy
MGI:3574427

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^dxnph/Prkdc^dxnph	129X1/SvJ	MGI:3574781
hm2	Prkdc^dxnph/Prkdc^dxnph	BALB/c	MGI:2663730
hm3	Prkdc^dxnph/Prkdc^dxnph	BALB/cJ	MGI:3574780
hm4	Prkdc^dxnph/Prkdc^dxnph	involves: BALB/cJ * 129X1/SvJ	MGI:3574895
cx5	Apc^Min/Apc⁺ Pla2g2a^Mom1-r/? Prkdc^dxnph/Prkdc^dxnph	involves: BALB/cByJ * C57BL/6	MGI:4461429
cx6	Dxmod/Dxmod Prkdc^dxnph/Prkdc^dxnph	involves: BALB/cJ * 129X1/SvJ	MGI:3574896

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

increased physiological sensitivity to xenobiotic ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

renal/urinary system

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

abnormal kidney morphology ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

glomerulosclerosis ( J:96632 )

• progress to significant glomerulosclerosis within 14 days of DOX injections

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cellular sensitivity to gamma-irradiation ( J:68487 )

• increased sensitivity to gamma irradition of mammary cells

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

increased physiological sensitivity to xenobiotic ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

renal/urinary system

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

abnormal kidney morphology ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

glomerulosclerosis ( J:96632 )

• progress to significant glomerulosclerosis within 14 days of DOX injections

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	involves: BALB/cJ * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:96632 )

• susceptibility to doxorubicin-induced proteinuria

renal/urinary system

increased urine protein level ( J:96632 )

• susceptibility to doxorubicin-induced proteinuria

glomerulosclerosis ( J:96632 )

• susceptibility to doxorubicin-induced glomerulosclerosis

Allelic Composition	Apc^Min/Apc⁺ Pla2g2a^Mom1-r/? Prkdc^dxnph/Prkdc^dxnph
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Pla2g2a^Mom1-r mutation (0 available); any Pla2g2a mutation (7 available)
Prkdc^dxnph mutation (0 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:83497 )

• mice show 2-3 fold increase in adenoma incidence in the small intestine after X-irradiation

Allelic Composition	Dxmod/Dxmod Prkdc^dxnph/Prkdc^dxnph
Genetic Background	involves: BALB/cJ * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dxmod mutation (0 available); any Dxmod mutation (0 available)
Prkdc^dxnph mutation (0 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

glomerulosclerosis ( J:96632 )

• susceptibility to doxorubicin-induced glomerulosclerosis

dilated renal tubule ( J:96632 )

• susceptibility to doxorubicin-induced microcystic tubular dilations

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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