Phenotypes associated with this allele

• Allele Symbol: Msmb^tm1Xuan
• Allele Name: targeted mutation 1, Jim W Xuan
• Allele ID: MGI:3574429
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msmb^tm1Xuan/Msmb^tm1Xuan	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3574653

Genotype
MGI:3574653

hm1

• Allelic Composition: Msmb^tm1Xuan/Msmb^tm1Xuan
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:96884 )

♂ • detected well-differentiated adenocarcinoma (prostate cancer) from 10 weeks of age and demonstrated a steadily prolonged cancer development, with a majority of well and moderately differentiated adenocarcinomas in almost all age groups

♂ • starting from age of 52 weeks, all mutant mice synchronously developed visible cancer and after 90 weeks, a few mice developed large tumor with endoneurocrine cancinoma tumor foci characterized

increased prostate intraepithelial neoplasia incidence ( J:96884 )

♂ • developed prostatic intraepithelial neoplasia immediately after puberty and saw prostatic intraepithelial neoplasia with microinvasion at 6-7 weeks in 69.9% of mutants

increased metastatic potential ( J:96884 )

• by age of 70 weeks and over, metastases to outside prostate organ to liver and lung were found in several mutants

endocrine/exocrine glands

enlarged prostate gland dorsolateral lobe ( J:96884 )

♂ • enlarged dorsolateral prostate lobes at 52 weeks of age

enlarged prostate gland ventral lobe ( J:96884 )

♂ • enlarged ventral prostate lobes at 52 weeks of age

increased prostate gland adenocarcinoma incidence ( J:96884 )

♂ • detected well-differentiated adenocarcinoma (prostate cancer) from 10 weeks of age and demonstrated a steadily prolonged cancer development, with a majority of well and moderately differentiated adenocarcinomas in almost all age groups

♂ • starting from age of 52 weeks, all mutant mice synchronously developed visible cancer and after 90 weeks, a few mice developed large tumor with endoneurocrine cancinoma tumor foci characterized

increased prostate intraepithelial neoplasia incidence ( J:96884 )

♂ • developed prostatic intraepithelial neoplasia immediately after puberty and saw prostatic intraepithelial neoplasia with microinvasion at 6-7 weeks in 69.9% of mutants

immune system

enlarged lymph nodes ( J:96884 )

• by 60 weeks of age, pelvic lymph nodes appeared as visible, enlarged glands

reproductive system

enlarged prostate gland dorsolateral lobe ( J:96884 )

♂ • enlarged dorsolateral prostate lobes at 52 weeks of age

enlarged prostate gland ventral lobe ( J:96884 )

♂ • enlarged ventral prostate lobes at 52 weeks of age

increased prostate gland adenocarcinoma incidence ( J:96884 )

♂ • detected well-differentiated adenocarcinoma (prostate cancer) from 10 weeks of age and demonstrated a steadily prolonged cancer development, with a majority of well and moderately differentiated adenocarcinomas in almost all age groups

♂ • starting from age of 52 weeks, all mutant mice synchronously developed visible cancer and after 90 weeks, a few mice developed large tumor with endoneurocrine cancinoma tumor foci characterized

increased prostate intraepithelial neoplasia incidence ( J:96884 )

♂ • developed prostatic intraepithelial neoplasia immediately after puberty and saw prostatic intraepithelial neoplasia with microinvasion at 6-7 weeks in 69.9% of mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:96884