Analysis Tools
mortality/aging
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• frequent perinatal lethality is seen
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growth/size/body
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• mutant pups are frequently smaller in stature at birth
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limbs/digits/tail
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• the number of tail vertebrae was reduced by 10 due to the loss of the caudal vertebrae without lateral processes
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short tail
(
J:68213
)
skeleton
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• the number of tail vertebrae was reduced by 10 due to the loss of the caudal vertebrae without lateral processes
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integument
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• increased proliferation of both epidermal and follicular keratinocytes is seen in the outer root shaft and suprabasal layer
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• seen in juvenile homozygotes most severely on the ventral and anterior-dorsal trunk and head
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• the cuticle had irregular or no septation in plucked mutant coat hair with frequnt fracturing near the root
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• thickened outer root sheaths
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• apparent in 5 day old homozygotes primarily the result of thickened outer root sheath
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• by 2-3 months of age many hair follicles have degenerated into cyst-like structures
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• the vibrissae display changes in cuticular septation with frequent lesions and the cuticles were generally denser and less well defined
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• the squamous cell layer is irregular and disorganized and contributes to the epidermal thickening
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• the suprabasal layer is irregular and disorganized and contributes to the epidermal thickening
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• apparent in 5 day old homozygotes
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flaky skin
(
J:68213
)
|
• in juveniles
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scaly skin
(
J:68213
)
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• ichthyosis is seen in adults
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• severely affected homozygotes display skin ulcerations
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tight skin
(
J:68213
)
|
• in newborns
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cellular
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• increased proliferation of both epidermal and follicular keratinocytes is seen in the outer root shaft and suprabasal layer
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