Phenotypes associated with this allele

• Allele Symbol: Ralgds^tm1Cjm
• Allele Name: targeted mutation 1, Christopher J Marshall
• Allele ID: MGI:3574574
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ralgds^tm1Cjm/Ralgds^tm1Cjm	involves: 129X1/SvJ * MF1	MGI:3575900

Genotype
MGI:3575900

hm1

• Allelic Composition: Ralgds^tm1Cjm/Ralgds^tm1Cjm
• Genetic Background: involves: 129X1/SvJ * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:96936 )

• a delay of four weeks in the onset of papillomas compared to controls when tumors are initiated in epidermal keratinocytes by topical application of 7,12-dimethylbenz[a]anthracene (DMBA)

• number of DMBA induced papillomas per animal was reduced by 4-fold compared to controls

decreased tumor growth/size ( J:96936 )

• significant reduction in the size of DMBA induced papillomas that developed compared to controls

• 4-fold increase in the number of apoptotic cells in DMBA induced papillomas compared to tumors from controls

• progression from papillomas to malignant carcinomas occurred more than 28 weeks after DMBA initiation, compared to 16 weeks in controls, with only 9% of tumors progressing to malignancy compared to 36% in controls

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:96936 )

• a delay of four weeks in the onset of papillomas compared to controls when tumors are initiated in epidermal keratinocytes by topical application of 7,12-dimethylbenz[a]anthracene (DMBA)

• number of DMBA induced papillomas per animal was reduced by 4-fold compared to controls