All Phenotypes Gnrhr<hh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnrhr^hh/Gnrhr^hh	involves: 129S6/SvEvTac * C57BL/6	MGI:3574973
hm2	Gnrhr^hh/Gnrhr^hh	involves: C57BL/6	MGI:5576345

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of male meiosis ( J:96941 )

• blocked at the midpachytene stages of meiosis

abnormal anogenital distance ( J:96941 )

• the anogenital distance is reduced

abnormal female reproductive system morphology ( J:96941 )

• the genital papilla is reduced in size

• overall the adult internal reproductive tract appears prepubescent

absent corpus luteum ( J:96941 )

absent tertiary ovarian follicles ( J:96941 )

• large antral follicles are absent

impaired ovarian folliculogenesis ( J:96941 )

• arrest at the early antral stage

uterus hypoplasia ( J:96941 )

• the uterus is thread-like and pale

abnormal male reproductive system morphology ( J:96941 )

• the genital papilla is reduced in size

• overall the adult internal reproductive tract appears prepubescent

small seminal vesicle ( J:96941 )

cryptorchism ( J:96941 )

small penis ( J:96941 )

small epididymis ( J:96941 )

• reduced in size

small gonad ( J:96941 )

small ovary ( J:96941 )

• ovaries are about 50% the size of normal littermates

decreased testis weight ( J:96941 )

• testes weigh 1/10 that of normal littermates

delayed vaginal opening ( J:96941 )

• opening of the vagina is delayed

homeostasis/metabolism

abnormal circulating hormone level ( J:96941 )

• decreased circulating levels of androstenedione

decreased circulating dihydrotestosterone level ( J:96941 )

decreased circulating testosterone level ( J:96941 )

decreased circulating progesterone level ( J:96941 )

decreased follicle stimulating hormone level ( J:96941 )

• the number of FSH positive cells is decreased in the pituitary

decreased circulating follicle stimulating hormone level ( J:96941 )

decreased luteinizing hormone level ( J:96941 )

• the number of LH positive cells is decreased in the pituitary

renal/urinary system

small penis ( J:96941 )

endocrine/exocrine glands

small seminal vesicle ( J:96941 )

absent corpus luteum ( J:96941 )

absent tertiary ovarian follicles ( J:96941 )

• large antral follicles are absent

impaired ovarian folliculogenesis ( J:96941 )

• arrest at the early antral stage

small ovary ( J:96941 )

• ovaries are about 50% the size of normal littermates

decreased testis weight ( J:96941 )

• testes weigh 1/10 that of normal littermates

cryptorchism ( J:96941 )

digestive/alimentary system

abnormal anogenital distance ( J:96941 )

• the anogenital distance is reduced

cellular

arrest of male meiosis ( J:96941 )

• blocked at the midpachytene stages of meiosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism 7 with or without anosmia		DOID:0090078	OMIM:146110	J:96941

Allelic Composition	Gnrhr^hh/Gnrhr^hh
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrhr^hh mutation (0 available); any Gnrhr mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating gonadotropin level ( J:211771 )

decreased circulating follicle stimulating hormone level ( J:211771 )

• significantly reduced in males relative to Gnrhr^tm1.1Bhr males

decreased circulating luteinizing hormone level ( J:211771 )

• significantly reduced in males relative to Gnrhr^tm1.1Bhr males

reproductive system

abnormal reproductive system morphology ( J:211771 )

abnormal ovary morphology ( J:211771 )

impaired ovarian folliculogenesis ( J:211771 )

• no follicles past the primary stage

small ovary ( J:211771 )

• very small ovaries

arrest of spermatogenesis ( J:211771 )

abnormal male reproductive system morphology ( J:211771 )

abnormal Leydig cell morphology ( J:211771 )

• Leydig cell defects

small testis ( J:211771 )

• reduced testis size

decreased testis weight ( J:211771 )

• testis weights reduced 94%

abnormal reproductive system physiology ( J:211771 )

absent estrous cycle ( J:211771 )

• anestrus

male infertility ( J:211771 )