Phenotypes associated with this allele

• Allele Symbol: Abca7^tm1Frm
• Allele Name: targeted mutation 1, Mason W Freeman
• Allele ID: MGI:3574592
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abca7^tm1Frm/Abca7^tm1Frm	involves: 129S4/SvJae * C57BL/6	MGI:3574816

Genotype
MGI:3574816

hm1

• Allelic Composition: Abca7^tm1Frm/Abca7^tm1Frm
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased white adipose tissue amount ( J:96865 )

• females, but not males, exhibited an approximate 50% reduction in the white adipose tissue mass at 10 weeks of age

homeostasis/metabolism

decreased circulating cholesterol level ( J:96865 )

• total cholesterol was significantly lower in females but not males, however no alterations in serum-free fatty acid levels

decreased circulating HDL cholesterol level ( J:96865 )

• females exhibited a decrease in HDL cholesterol levels

renal/urinary system

small kidney ( J:96865 )

• males exhibit a 10% reduction in kidney size at 10 weeks of age